Table 5.
Comparison of Observed 12-month cognitive scores from the validation sample and Predicted 12-month scores based on SRBs from the development sample.
| Observed 12-month | Predicted 12-month | r | R2 | p value | Effect Size | |
|---|---|---|---|---|---|---|
| RAVLT | ||||||
| Total Recall | 45.41 (10.6) | 44.68 (7.5) | .68 | .46 | .20 | 0.09 |
| Delayed Recall | 8.35 (4.1) | 9.30 (2.3) | .62 | .38 | <.001 | −0.30 |
| Logical Memory | ||||||
| Immediate Recall | 15.16 (3.2) | 14.85 (1.8) | .54 | .29 | .12 | 0.11 |
| Delayed Recall | 13.83 (3.7) | 14.90 (2.6) | .53 | .28 | <.001 | −0.34 |
| ADAS-Cog | 8.26 (4.2) | 8.37 (3.0) | .68 | .46 | .53 | −0.05 |
| Clock Drawing | 4.71 (0.6) | 4.72 (0.3) | .24 | .06 | .80 | −0.02 |
| Clock Copy | 4.87 (0.4) | 5.06 (0.1) | .25 | .06 | <.001 | −0.51 |
| DS Forward | 8.78 (1.8) | 8.62 (1.3) | .68 | .46 | .25 | 0.12 |
| DS Backward | 7.50 (2.2) | 7.06 (1.7) | .55 | .30 | .03 | 0.23 |
| Digit Symbol | 48.40 (11.3) | 48.96 (9.9) | .76 | .58 | .46 | −0.07 |
| Animal Fluency | 21.08 (5.1) | 21.89 (3.7) | .63 | .39 | .006 | −0.20 |
| Vegetable Fluency | 14.63 (3.8) | 14.82 (3.3) | .54 | .29 | .58 | −0.05 |
| TMT-A | 31.90 (9.7) | 33.05 (6.8) | .55 | .30 | .06 | −0.14 |
| TMT-B | 80.10 (41.8) | 77.50 (18.5) | .57 | .32 | .31 | 0.07 |
| BNT | 28.63 (1.9) | 28.58 (1.3) | .68 | .46 | .67 | 0.03 |
| MMSE | 29.10 (1.3) | 29.24 (0.4) | .18 | .03 | .06 | −0.11 |
| MOCA | 25.90 (2.6) | 26.75 (1.4) | .58 | .33 | <.001 | −0.40 |
Note: RAVLT = Rey Auditory Verbal Learning Test, ADAS-Cog = Alzheimer’s Disease Assessment Scale – Cognition subscale, DS = Digit Span, TMT-A = Trail Making Test Part A, TMT-B = Trail Making Test Part B, BNT = Boston Naming Test, MMSE = Mini-Mental State Examination, MOCA = Montreal Cognitive Assessment. r = bivariate correlation between Observed 12-month and Predicted 12-month performances for each measure. R2 = proportion of variability accounted for by correlation between Observed 12-month and Predicted 12-month cognitive scores. p value = significance of paired sample t tests Observed 12-month and Predicted 12-month cognitive scores. Effect Size = Cohen’s d value for paired sample t tests. All correlations greater than r = .25 were significant at p < .001.