Table 7.
Regression equations for predicting 12-month Follow-up scores from the combined development and validation samples (n = 384).
| F(df), p | Predicted M12 | R 2 | SEest | ||
|---|---|---|---|---|---|
| RAVLT | Total Recall | F(7, 376) = 52.74, p < .001 | 22.19 + (BL*0.67) – (retest interval*0.04) – (M06 assessment*0.04) – (age*0.10) + (education*0.43) + (sex*2.56) + (ethnicity*2.84) | .50 | 7.48 |
| Delayed Recall | F(7, 376) = 34.14, p < .001 | 6.10 + (BL*0.58) – (retest interval*0.008) – (M06 assessment *0.98) – (age*0.04) + (education*0.15) + (sex*0.86) + (ethnicity*0.80) | .39 | 3.14 | |
| Logical Memory | Imm. Recall | F(7, 376) = 24.93, p < .001 | 8.51 + (BL*0.55) – (retest interval*0.01) – (M06 assessment *0.32) – (age*0.01) + (education*0.07) + (sex*1.02) + (ethnicity*0.58) | .32 | 2.80 |
| Delayed Recall | F(7, 376) = 28.46, p < .001 | 11.40 + (BL*0.65) – (retest interval*0.02) – (M06 assessment *0.61) – (age*0.03) + (education*0.08) + (sex*0.93) + (ethnicity*0.28) | .35 | 3.20 | |
| ADAS-Cog | F(7, 370) = 43.94, p < .001 | 1.42 + (BL*0.57) + (retest interval*0.01) – (M06 assessment *3.38) + (age*0.08) – (education*0.16) – (sex*1.01) – (ethnicity*0.39) | .45 | 3.32 | |
| Clock Drawing | F(7, 376) = 5.10, p < .001 | 4.11 + (BL*0.22) + (retest interval*0.001) – (M06 assessment *0.07) – (age*0.01) + (education*0.01) + (sex*0.04) – (ethnicity*0.03) | .09 | 0.59 | |
| Clock Copy | F(7, 375) = 4.73, p < .001 | 3.79 + (BL*0.18) + (retest interval*0.001) – (M06 assessment *0.02) – (age*0.005) + (education*0.01) + (sex*0.09) – (ethnicity*0.08) | .08 | 0.36 | |
| DS Forward | F(7, 185) = 22.78, p < .001 | 3.24 + (BL*0.67) + (retest interval*0.0081) – (M06 assessment *1.07) – (age*0.03) + (education*0.01) + (sex*0.01) – (ethnicity*0.17) | .46 | 1.47 | |
| DS Backward | F(7, 185) = 22.11, p < .001 | 0.65 + (BL*0.66) + (retest interval*0.006) + (M06 assessment *2.56) – (age*0.04) + (education*0.06) + (sex*0.19) – (ethnicity*0.61) | .46 | 1.71 | |
| Digit Symbol | F(7, 184) = 50.62, p < .001 | 17.46 + (BL*0.84) – (retest interval*0.005) – (M06 assessment *0.75) – (age*0.11) – (education*0.04) + (sex*1.79) + (ethnicity*0.47) | .66 | 6.38 | |
| Animal Fluency | F(7, 376) = 43.22, p < .001 | 19.39 + (BL*0.57) – (retest interval*0.004) + (M06 assessment *0.26) – (age*0.13) + (education*0.12) – (sex*0.44) – (ethnicity*0.60) | .45 | 3.95 | |
| Veg. Fluency | F(7, 185) = 20.99, p < .001 | 10.58 + (BL*0.58) – (retest interval*0.005) + (M06 assessment *0.91) – (age*0.11) + (education*0.17) + (sex*1.52) – (ethnicity*0.14) | .44 | 3.14 | |
| TMT-A | F(7, 374) = 36.46, p < .001 | 17.92 + (BL*0.48) – (retest interval*0.04) – (M06 assessment *1.33) + (age*0.27) – (education*0.27) – (sex*1.04) + (ethnicity*0.05) | .41 | 7.67 | |
| TMT-B | F(7, 374) = 28.21, p < .001 | −16.84 + (BL*0.47) – (retest interval*0.07) – (M06 assessment *9.44) + (age*1.23) – (education*0.83) – (sex*1.86) + (ethnicity*15.25) | .35 | 32.17 | |
| BNT | F(7, 346) = 47.36, p < .001 | 15.98 + (BL*0.56) – (retest interval*0.003) – (M06 assessment *0.02) – (age*0.04) + (education*0.04) – (sex*0.07) + (ethnicity*0.16) | .49 | 1.26 | |
| MMSE | F(7, 376) = 5.76, p < .001 | 22.25 + (BL*0.30) + (retest interval*0.001) – (M06 assessment *0.19) – (age*0.03) + (education*0.001) + (sex*0.12) + (ethnicity*0.007) | .10 | 1.23 | |
| MOCA | F(7, 183) = 15.00, p < .001 | 17.66 + (BL*0.47) – (retest interval*0.003) – (M06 assessment *0.30) – (age*0.08) + (education*0.17) + (sex*0.40) + (ethnicity*0.06) | .37 | 2.06 | |
Note: All scores are raw scores. RAVLT = Rey Auditory Verbal Learning Test, Imm. Recall = Immediate Recall, ADAS-Cog = Alzheimer’s Disease Assessment Scale – Cognition subscale, DS = Digit Span, Veg. Fluency = Vegetable Fluency, TMT-A = Trail Making Test Part A, TMT-B = Trail Making Test Part B, BNT = Boston Naming Test, MMSE = Mini-Mental State Examination, MOCA = Montreal Cognitive Assessment. Test interval is in days, age and education are in years, M06 assessment (6-month assessment) is coded as absent = 0 and present = 1, sex is coded as male = 1 and female = 2, and ethnicity is coded as Caucasian/Non-Hispanic = 1 and Non-Caucasian/Hispanic = 2. R2 = squared value of Pearson’s correlation coefficient for Baseline and 12-month scores, SEest = Standard error of the estimate.