. Author manuscript; available in PMC: 2023 Aug 1.

Published in final edited form as: J Neural Transm (Vienna). 2022 Jun 26;129(8):1001–1009. doi: 10.1007/s00702-022-02523-3

Table 3.

Relationship between composite topographic measure of VSCD-cholinergic network changes and the presence of imbalance, falls and FoG in persons with PD (n=54).

VAChT region	PIGD status subgroup model	Age	Duration	Gender	Striatal dopamine [¹¹C]DTBZ PET	Total model
Composite of 5 VSCD model-selected regions	Imbalance status F=6.5, P=0.015 (8.3%^* lower in HY ≥2.5 stage)	F=6.2, P=0.017	F=0.0, P=0.96	F=6.6, P=0.014	F=2.2, P=0.15	R²=0.35, F=5.1, P=0.0008
Composite of 5 VSCD model-selected regions	Fall status F=4.9, P=0.03 (6.9%^* lower in fallers)	F=9.2, P=0.004	F=0.2, P=0.63	F=3.5, P=0.07	F=1.0, P=0.33	R²=0.33, F=4.7, P=0.0015
Composite of 5 VSCD model-selected regions	FoG status F=9.0, P=0.0043 (14.2%^* lower in freezers)	F=6.3, P=0.016	F=0.6, P=0.45	F=3.7, P=0.06	F=0.1, P=0.76	R²=0.39, F=5.8, P=0.0003

ANCOVA F-values (with levels of significance) are listed for the group effects and age, duration of disease, gender, striatal dopamine [¹¹C]DTBZ PET binding and total model effects. FoG = freezing of gait.

covariate adjusted