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. Author manuscript; available in PMC: 2023 Jul 8.
Published in final edited form as: Circ Res. 2022 Jun 17;131(2):e22–e33. doi: 10.1161/CIRCRESAHA.122.320877

Table 3:

Multivariable logistic regression model for the association of IL-6 with carotid plaque progression at 5 years

Independent variables OR1 (95% CI) * p-value OR2† OR3 (95% CI) ‡
Log IL-6 1.44 (1.23 – 1.69) 9.1 × 10−6 1.24 1.34 (1.18 – 1.53)
Current smoker 1.64 (1.20 – 2.25) 1.6 × 10−3 1.16 1.50 (1.16 – 1.93)
Dyslipidemia 2.32 (1.64 – 3.30) 2.3 × 10−6 1.26 1.98 (1.50 – 2.63)
Diabetes mellitus 1.46 (1.09 – 1.95) 1.1 × 10−2 1.13 1.36 (1.07 – 1.72)
Hypertension 1.37 (1.12 – 1.66) 1.5 × 10−3 1.17 1.29 (1.10 – 1.51)
Coronary heart disease 1.37 (1.03 – 1.83) 3.0 × 10−2 1.12 1.29 (1.03 – 1.63)
Male 1.28 (1.05 – 1.56) 1.3 × 10−2 1.13 1.22 (1.04 – 1.43)
Age (years) 1.03 (1.01 – 1.05) 6.4 × 10−3 1.14 1.02 (1.01 – 1.04)
Vulnerability at baseline (ipsilateral) 0.77 (0.61 – 0.97) 2.0 × 10−2 0.89 0.81 (0.67 – 0.97)
Stenosis score at baseline (ipsilateral) 0.24 (0.21 – 0.28) 1.7 × 10−92 0.27 0.32 (0.28 – 0.35)
Intercept (baseline odds) 0.08 (0.02 – 0.37) 9.8 × 10−4 NA 0.52 (0.13–2.41)

IL-6: interleukin-6; NA: not applicable.

*

Non-standardized odds ratio (linked to change in odds per 1 unit increase)

†

Standardized odds ratio (linked to change in odds per 1 standard deviation increase)

‡

Optimism-adjusted odds ratio using the heuristic shrinkage method.

The first interaction term (Log IL-6 # ipsilateral vulnerability at baseline, p = 0.99), atrial fibrillation, treatment with anti-inflammatory drugs, race, history of stroke or transient ischemic attack, alcohol consumption, the second interaction term (Log IL-6 # ipsilateral baseline stenosis score), body mass index, log C-reactive protein, treatment with antiplatelet drugs, peripheral artery disease, hyperuricemia, and cystatin-based glomerular filtration rate (p=0.06) were consecutively removed from the model automatically due to coefficients with p-value >0.05.

Likelihood ratio chi-squared test for significance of the model: χ2 = 712.2, df = 10, p = 1.5 × 10−146. Area under the Receiver Operating Characteristic curve = 0.80. Count R2 = 73%. Proportion of patients correctly classified = 73.4%. Maximum Cook distance = 0.07. Maximum variance inflation factor = 1.15.

The p values for significance of the odds ratios were determined by a Wald test.