. 2022 Jul 23;12:12598. doi: 10.1038/s41598-022-14243-5

Table 1.

Cytotoxicity (CC₅₀ and CC₂₀), antiviral potency (IC₅₀) and selectivity index (SI) of ouabain.

Cell line	CC₅₀ (nM)^a	CC₂₀ (nM)^b	Pre-treatment		Post-treatment
Cell line	CC₅₀ (nM)^a	CC₂₀ (nM)^b	IC₅₀ (nM)^c	SI^d	IC₅₀ (nM)^c	SI^d
Vero	68.9	20	2.33	29.5	1.92	35.8

^aCC₅₀ (50% cytotoxic concentration) refers to compound concentration that caused a 50% reduction in viability.

^bCC₂₀ (20% cytotoxic concentration) refers to the maximum non-toxic concentration employed in the antiviral assays.

^cIC₅₀ (50% inhibitory concentration) refers to compound concentration required to reduce viral titers by 50% compared with untreated controls.

^dThe Selectivity Index (SI) is obtained by calculating the ratio of the CC₅₀ to the IC₅₀.