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. 2022 Jul 23;13:4264. doi: 10.1038/s41467-022-31780-9

Fig. 3. Correlation of tumor mutational burden (TMB), microsatellite instability high (MSI-H), and PD-L1 expression in OM cohort.

Fig. 3

a The tumor-type-specific distribution of TMB (excluding samples with TMB of 0) between the aOM cohort (light red) and the MSK cohort (light blue). Tumor types were sorted from left to right based on median TMB values (y-axis). The total number of samples was shown for each tumor type. P values were labeled on the top of corresponding tumor types in which TMB was significantly different between cohorts and calculated using a two-sided Wilcoxon rank-sum test. The boxplot elements indicate the maxima, 75th percentile, median, 25th percentile, and minima. Notches are used to compare groups; if the notches of two boxes do not overlap, this suggests that the medians are significantly different. b Distribution of TMB density between the aOM cohort (light red) and the MSK cohort (light blue). c The tumor-type-specific distribution for 186 samples with MSI-H. d The analysis for the cohort-level or tumor type-specific correlation of TMB, MSI, and PD-L1 expression in 2,723 samples with available information on MSI, TMB, and PD-L1. The Venn diagram showed the proportion of TMB-H (light blue), PD-L1 positive (light purple), and MSI-H (light green). Total proportions, numbers of samples with at least MSI-H, TMB-H, or PD-L1 positive, and total numbers of samples were shown in parentheses.