表 1.
急性胰腺炎患者各实验室指标的比较
Demographic and laboratory data of patients
| Variables | SAP | P | Mortality | P | ||
| Yes(n=52) | No (n=123) | Yes (n=12) | No (n=163) | |||
| PLT: Platelet; vWF: Ag: Von willebrand factor antigen; PT: Prothrombin time; APTT: Activated partial thromboplastin time; FIB: Fibrinogen; TT: Thrombin time; PC: Protein C; PS: Protein S; AT Ⅲ : Antithrombin III; PLG: Plasminogen; ad: At admission; max: Maximum; min: Minimum; △: (max-ad) or (ad-min). normally distributed continuous variables were reported as Mean±SD, skewed continuous variables were reported as Median. | ||||||
| Demographic features | ||||||
| Age (year) | 46.7±14.0 | 48.6±15.7 | 0.502 | 47.6±14.8 | 48.1±15.3 | 0.907 |
| Male [n (%)] | 30 (75.0%) | 76 (61.8%) | 0.181 | 10 (83.3%) | 106 (65.0%) | 0.342 |
| BMI (kg/m2) | 26.0±3.6 | 25.2±4.4 | 0.318 | 28.1±2.4 | 25.4±4.3 | 0.047 |
| Laboratory markers | ||||||
| PLT | ||||||
| PLTad(109/L) | 155.2±83.8 | 173.2±73.8 | 0.160 | 155.8±64.7 | 168.7±78.1 | 0.575 |
| PLTmin(109/L) | 105.7±61.1 | 146.9±59.5 | < 0.001 | 87.2±50.8 | 138.1±62.2 | 0.006 |
| △PLT(109/L) | 26.0(5.5, 112.0) | 34.0 (0.0, 66.0) | 0.034 | 44.0 (22.0, 92.5) | 13.0 (0.0, 43.0) | 0.005 |
| vWF: Ag | ||||||
| vWF: Agad(%) | 319.7±110.6 | 221.6±98.1 | < 0.001 | 368.6±126.1 | 241.6±105.1 | < 0.001 |
| vWF: Agmax(%) | 370.6±139.1 | 236.6±105.8 | < 0.001 | 410.1 (335.4, 505.2) | 267.0 (168.6, 333.6) | < 0.001 |
| △vWF: Ag(%) PT | 2.6 (0.0, 149.1) | 23.8 (0.0, 51) | 0.006 | 40.5 (0.0, 233.4) | 0.0 (0.0, 6.8) | 0.026 |
| PT | ||||||
| PTad(s) | 14(12.1, 15.9) | 13.2 (12.8, 14.1) | 0.002 | 14 (12.2, 17.0) | 12.4 (11.6, 13.5) | 0.014 |
| PTmax(s) | 15.8 (13.9, 18.1) | 14.6 (13.8, 17.1) | < 0.001 | 21 (16.1, 27.0) | 13.5 (12.2, 14.8) | < 0.001 |
| △PT(s) | 2.0 (0.9, 3.9) | 1.4 (0.0, 2.0) | < 0.001 | 5.9(2, 15.4) | 0.7 (0.0, 1.7) | < 0.001 |
| APTT | ||||||
| APTTad(s) | 30.0 (24.7, 33.0) | 28.9 (25.4, 33.4) | 0.105 | 29.5 (25.6, 34.7) | 29.6 (26.9, 32.8) | 0.710 |
| APTTmax(s) | 33.8 (33.2, 48.2) | 32.5 (29.4, 35.4) | < 0.001 | 51.0 (37.1, 74.8) | 32.2 (29.1, 35.4) | < 0.001 |
| △APTT(s) | 3.1 (0.0, 22.3) | 2.3 (1.2, 7.7) | < 0.001 | 20.5 (4.8, 45.8) | 1.2 (0.0, 4.5) | < 0.001 |
| FIB | ||||||
| FIBad(g/L) | 3.9 (2.9, 5) | 4.3 (2.8, 4.9) | 0.210 | 3.6 (2.6, 6.0) | 4.4 (3.4, 6.5) | 0.171 |
| FIBmin(g/L) | 3.1 (2.1, 4.1) | 3.8 (3, 5.1) | 0.001 | 2.1 (1.8, 2.4) | 3.7 (2.8, 4.8) | < 0.001 |
| △FIB(g/L) | 1.4 (0.5, 3) | 0.0 (0.0, 0.5) | < 0.001 | 1.3 (0.0, 4.7) | 0.0(0.0, 1.5) | 0.015 |
| TT | ||||||
| TTad(s) | 18.5 (16.8, 19.4) | 17 (16.55, 19.1) | 0.985 | 18.7 (17.3, 21.2) | 17.6(16.7, 18.8) | 0.053 |
| TTmax(s) | 19.9 (18.5, 22.0) | 18.4 (17.8, 20.1) | 0.001 | 22.8 (18.9, 26.9) | 18.4 (17.6, 19.4) | < 0.001 |
| △TT(s) | 1.5 (0.4, 4.1) | 0.7 (0.1, 2.6) | < 0.001 | 1.9 (0.2, 6.4) | 0.0(0.0, 1.4) | 0.004 |
| PC | ||||||
| PCad(%) | 65.0 (38.6, 84.9) | 74.7 (66.7, 107.4) | < 0.001 | 57.4 (44.5, 72.3) | 79.2 (61.8, 105.8) | 0.012 |
| PCmin(%) | 59.7 (38.6, 84.5) | 71.3 (51.3, 84.9) | < 0.001 | 31.2 (24, 54) | 73.8 (58.9, 95.4) | < 0.001 |
| △PC(%) | 0.0 (0.0, 7.7) | 0.0 (0.0, 25.2) | < 0.001 | 10.2 (0.0, 32) | 0.0 (0.0, 12.1) | 0.001 |
| PS | ||||||
| PSad(%) | 63.7 (48.8, 81.7) | 68.3 (52.7, 73.0) | 0.300 | 41.0±26.0 | 63.4±24.1 | 0.057 |
| PSmin(%) | 47.6±25.7 | 61.9±22.4 | 0.043 | 35.9±29.5 | 58.7±23.1 | 0.046 |
| △PS(%) | 0.0 (0.0, 6.4) | 0.0 (0.0, 3.3) | 0.350 | 0.0 (0.0, 12.9) | 0.0 (0.0, 0.0) | 0.437 |
| AT Ⅲ | ||||||
| AT Ⅲad(%) | 69.3 (57.3, 84.5) | 73.0 (65, 83.6) | < 0.001 | 68.8±14.6 | 76.9±18.1 | 0.135 |
| AT Ⅲmin(%) | 61.7 (47.6, 67.3) | 70.0 (57.1, 76.8) | < 0.001 | 38.2±16.2 | 71.1±19.1 | < 0.001 |
| AT Ⅲ(%) | 6.2 (2.5, 19.7) | 4.1 (0.0, 23.1) | < 0.001 | 23.8 (14.1, 52.5) | 1.3 (0.0, 10.5) | < 0.001 |
| PLG | ||||||
| PLGad(%) | 107.8±24.9 | 105.5±16.4 | 0.669 | 103.6±20.4 | 107.0±20.8 | 0.665 |
| PLGmin(%) | 91.4±18.5 | 96.0±18.6 | 0.341 | 81.2±18.7 | 95.8±17.9 | 0.038 |
| △PLG(%) | 14.0 (0.0, 26.9) | 7.3 (0.0, 29.8) | 0.014 | 23.1 (11.1, 36.0) | 3.8 (0.0, 20.6) | 0.031 |
| D-dimer | ||||||
| D-dimerad (mg/LFEU) | 3.9 (1.7, 12.6) | 3.5 (1.8, 4.4) | < 0.001 | 4.1 (2.1, 6.7) | 2.5 (1.1, 6.7) | 0.197 |
| D-dimermax(mg/LFEU) | 12.5 (5.3, 17.2) | 8.9 (7.6, 16.2) | < 0.001 | 14.3 (10.6, 17.9) | 7.0 (2.0, 13.4) | 0.002 |
| △D-dimer (mg/LFEU) | 5.9 (3.8, 14.1) | 3.8 (0.0, 8.7) | < 0.001 | 8.5 (3.0, 16.2) | 1.1 (0.0, 6.2) | 0.001 |