Table 2.
Uni- and multivariate analysis of preoperative predictors of AL
| Development cohort | |||||
|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | ||||
| OR (95% CI) | p | OR (95% CI) | p | ||
| Age (years) | (≥ 60/ < 60) | 5.046 (1.785-14.263) | < 0.001 | 5.890 (1.701-27.623) | 0.012 |
| Sex | (Female/male) | 0.501 (0.254-0.984) | 0.041 | 0.420 (0.170-0.941) | 0.044 |
| BMI (Kg/m.2) | 0.555 (0.294-1.047) | 0.883 | |||
| Smoking | (Yes/No) | 1.176 (0.552-2.507) | 0.674 | ||
| Alcohol | 1.666 (0.749-3.707) | 0.207 | |||
| Abdominal operation | (Yes/No) | 0.798 (0.376-1.691) | 0.555 | ||
| T2DM | (Yes/No) | 0.891 (0.310-2.565) | 0.831 | ||
| Cardiovascular disease | (Yes/No) | 0.405 (0.096-1.707) | 0.203 | ||
| Hypertension | (Yes/No) | 0.743 (0.369-1.495) | 0.403 | ||
| COPD | (Yes/No) | 1.518 (0.519-4.444) | 0.443 | ||
| Hepatitis | (Yes/No) | 0.648 (0.086-4.912) | 0.672 | ||
| Kidney disease | (Yes/No) | 0.942 (0.122-7.266) | 0.954 | ||
| Hyperlipidemia | (Yes/No) | 1.006 (0.130-7.792) | 0.995 | ||
| Transfusion history | (Yes/No) | 0.957 (0.942-0.973) | 0.157 | ||
| Bowel preparation | (Yes/No) | 0.999 (0.996-1.001) | 0.797 | ||
| Hemoglobin (g/L) | (≥ 90/ < 90) | 0.190 (0.102-0.355) | < 0.001 | 0.270 (0.120-0.643) | 0.001 |
| Tumor location | Transverse colon descending, sigmoid colon rectum | 0.291 (0.009-9.958) | 0.003 | 3.940 (2.100-8.610) | < 0.001 |
| NRS2002 | (≥ 3/ < 3) | 4.503 (2.319-8.743) | < 0.001 | 3.240 (1.441-7.741) | 0.006 |
| LCR | (> 6000/ ≤ 6000) | 0.171 (0.060-0.482) | < 0.001 | 0.180 (0.053-0.530) | 0.003 |
| ASA score | (I/II/III/IV) | 0.386 (0.002-63.381) | 0.048 | 1.260 (0.681-2.310) | 0.510 |
| ECOG score | (0/1/2/3/4) | 16.556 (0.610-49.231) | 0.005 | 0.862 (0.490-1.510) | 0.610 |
| Total bilirubin(μmol/L) | 1.007 (0.863-1.175) | 0.280 | |||
| Direct bilirubin(μmol/L) | 1.537 (0.328-7.190) | 0.088 | |||
| ALT (IU/L) | 0.930 (0.684-1.265) | 0.895 | |||
| AST (IU/L) | 0.879 (0.617-1.254) | 0.298 | |||
| Prealbumin (g/L) | 0.224 (0.004-12.783) | 0.684 | |||
| Albumin (g/L) | 0.956 (0.611-1.497) | 0.435 | |||
| Urea (mmol/L) | 0.329 (0.060-1.787) | 0.848 | |||
| Creatinine (μmol/L) | 0.915 (0.776-1.080) | 0.583 | |||
| Uric acid (μmol/L) | 1.002 (0.972-1.033) | 0.980 | |||
| White blood count (109/L) | 0.466 (0.084-1.213) | 0.497 | |||
| Neutrophil count (109/L) | 0.684 (0.103-1.641) | 0.290 | |||
| Lymphocyte count (109/L) | 1.445 (0.227-10.360) | 0.229 | |||
| Hematocrit (%) | 1.048 (0.937-1.172) | 0.848 | |||
| Platelet count (109/L) | 0.973 (0.933-1.015) | 0.468 | |||
| APTT(s) | 1.067 (0.689-1.651) | 0.578 | |||
| PT(s) | 3.085 (0.188-50.598) | 0.986 | |||
| INR | 6.011 (1.308-15.855) | 0.646 | |||
| C-reactive protein(ng/L) | 2.364 (0.985-5.215) | 0.001 | 1.031 (0.990-1.060) | 0.040 | |
BMI body mass index, ASA American Society of Anesthesiologists, ECOG Eastern Cooperative Oncology Group, COPD Chronic Obstructive Pulmonary Disease, NRS2002 Nutritional Risk Screening 2002, LCR Lymphocyte-C-reactive protein Ratio, ALT alanine aminotransferase, AST aspartate aminotransferase, T2DM type 2 diabetes mellitus, APTT activated partial thromboplasin time, PT prothrombin time, INR international normalized ration