Table 1.

Baseline characteristics of the included trials

Study	Publication year	Type	Country	Lesion type	DES type	Study total size	Randomization	MACE	Follow up (month)
AIR-CTO [13]	2015	RCT	China	CTO	First/Second generation	115/115	IVUS VS Angiography	All-cause death, MI, TLR, ST	24
AVIO [14]	2013	RCT	European countries	Complex lesionsa	First generation	142/142	IVUS VS Angiography	Cardiac death, MI or TVR	24
CTO-IVUS [15]	2015	RCT	Korea, America	CTO	New-generation	201/201	IVUS VS Angiography	Cardiac death, MI or TVR	12
HOME DES IVUS [23]	2010	RCT	Czech Republic	Complex lesionsa	First generation	105/105	IVUS VS Angiography	All-cause death, MI or TLR	18
ILUMIEN III [21]	2021	RCT	America	Non-complex lesions	NR	289/142	IVUS + OCT VS Angiography	Cardiac death, MI or TLR	12
iSIGHT [34]	2021	RCT	Brazil	Long lesions, Non–unprotected left main	Second/ New-generation	101/49	IVUS + OCT VS Angiography	Cardiac death, MI and TLR	30
IVUS-XPL [16]	2015	RCT	Korea	Long lesions	New-generation	700/700	IVUS VS Angiography	Cardiac death, MI or TLR	12
Kala et al. [22]	2016	RCT	Czech Republic, America	All comer	Second/ New-generation	105/96	OCT VS Angiography	All-cause death, MI, and TLR	9
Kim et al. [17]	2013	RCT	Korea	Long lesions	Second generation	297/246	IVUS VS Angiography	Cardiac death, MI, TVR or ST	12
Liu et al. [18]	2019	RCT	China	Unprotected left main	NR	167/169	IVUS VS Angiography	Cardiac death, MI or TVR	12
RESET [24]	2013	RCT	Korea	Non-complex lesions	Second generation	662/912	IVUS VS Angiography	Cardiac death, MI or TVR	12
Tan et al. [19]	2015	RCT	China	Unprotected left main	First generation	61/62	IVUS VS Angiography	All-cause death, MI, TLR	24
ULTIMATE [20]	2021	RCT	China	Long lesions	Second generation	714/709	IVUS VS Angiography	Cardiac death, MI or TVR	36

RCT randomized controlled trial; CTO chronic total occlusion; IVUS intravascular ultrasound; OCT optical coherence tomography; DES drug-eluting stent; MI myocardial infarction; TLR target lesion revascularization; ST stent thrombosis; TVR target vessel revascularization; RCR repeat coronary revascularization; NR not reported

^aBased on the trials included, complex lesions were defined as one of the following: lesion type B2 and C according to the American Heart Association; chronic total occlusions (CTO); bifurcation lesions; proximal left anterior descending artery; long lesions (> 20 mm); small vessels (reference vessel diameter ≤ 2.5 mm); left main coronary artery lesions and patients requiring 4 or more stents; insulin dependent diabetes mellitus and acute coronary syndrome