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. Author manuscript; available in PMC: 2022 Jul 24.
Published in final edited form as: Cell Rep. 2022 Jul 12;40(2):111058. doi: 10.1016/j.celrep.2022.111058

KEY RESOURCES TABLE

REAGENT or RESOURCE SOURCE IDENTIFIER
Antibodies
α-Synuclein Abcam ab138501 (MJFR1)
α-Synuclein BD Bioscience 610787; AB_398107
Phospho Ser129 α-synuclein Abcam ab51253 (EP1536Y)
Tyrosine hydroxylase (TH) Pel-Freeze Biologicals P40101
PPARα Santacruz sc-398394
PPARβ Santacruz sc-74517
PPARγ Santacruz sc-7273
PGC1α Millipore AB3242
TFEB Abcam ab2636
Lamp2 Millipore MABC40; AB_2662613
Cathepsin D Santacruz sc-6487
TPP1 Abcam ab54685
Actin Abcam ab8226
Chemicals, peptides, and recombinant proteins
Recombinant human α-syn Anaspec AS-1000
Fenofibrate Millipore Sigma F6020-100G
SYBR green real-time kit QuantaBio K1070
Proteinase K Sigma 3115828001
IRDye infrared dye end-labeled oligonucleotide probe for PPAR Li-COR Biosciences Custom made
Deposited data
Raw and analyzed data Figshare https://doi.org/10.6084/m9.figshare.20032727
Experimental models: Organisms/strains
M83 (A53T) Jackson Laboratory B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J
CLN2−/− Ghosh et al., 2017 https://doi.org/10.1111/jnc.13987
C57BL6 Envigo C57BL/6JOlaHsd
PPARα−/− Jackson Laboratory B6; 129S4-Pparatm1Gonz/J
Oligonucleotides
Primers for lysosomal genes, see Table S2 This paper NA
Primer corresponding to Tfeb promoter, sense: 5′-GAA CAT TCC AGG TGG AGG CA-3′ This paper NA
Primer corresponding to Tfeb promoter, antisense: 5′-CCC CCA ACA CAT GCT TCT CT-3′ This paper NA
Software and algorithms
Fiji (ImageJ2) Schneider et al., 2012 https://doi.org/10.1038/nmeth.2089
Morpheus Broad Institute https://software.broadinstitute.org/morpheus/
GraphPad Prism v7.02 GraphPad Software Inc. https://www.graphpad.com/scientific-software/prism/