| AS1974 |
127nt |
PA185388(R3)_471298-471425 |
Yes |
Not describe |
Master regulator regulating multiple drug resistance pathways, including membrane transporters and biofilm associated drug resistance genes, the expression of which is regulated by gene 5′UTR methylation sites; it was able to transform multi drug resistant clinical strains into drug highly susceptible strains when overexpressed (Law et al., 2019). |
| CrcZ |
407nt |
PAO1_5,308,587-5,308,993 |
Yes |
Crc,Hfq |
RpoN and CbrA/CbrB are required for crcZ expression. The CbrA-CbrB-CrcZ-Crc system enables bacteria to adapt to different carbon sources (Sonnleitner, Abdou & Haas, 2009). CrcZ binding to Hfq can sequester Hfq and affect multiple Hfq involved physiological activities: ① abolishes Hfq mediated translational repression of amiE mRNA (Sonnleitner & Blasi, 2014); ② indirectly affects biofilm formation by competing for Hfq (Pusic et al., 2016); ③ interferes with PrrF1-2/Hfq mediated regulation of the antR (Sonnleitner, Prindl & Blasi, 2017); ④ correlation with bacterial susceptibility to antibiotics (Pusic et al., 2018; Xia et al., 2020a; Xia et al., 2020b). |
| P27 |
192nt |
PAO1_4781786-4781978 |
Yes |
rhlI mRNA |
Fine tuning the activity of the rhl QS system (Chen et al., 2019). |
| PA0805.1 |
276nt |
PAO1_883,307–883,582 |
Not describe |
Not describe |
Associated with P. aeruginosa motility, adhesion, cytotoxicity and tobramycin resistance (Coleman et al., 2020; Gill et al., 2018). |
| PA2952.1 |
117nt |
PA14_3,312,577–3,312,693 |
Not describe |
Not describe |
PA2952. 1 affects P. aeruginosa virulence, motility, and antibiotic resistance, with links to several proteins and genes (Coleman et al., 2021; Gill et al., 2018). |
| PaiI |
126nt |
PA14_13970-13990 |
Yes |
Not describe |
Induced in an anaerobic environment in the presence of nitrate, and transcription of PaiI is dependent on the two-component system NarX/L; PaiI has an important role in adaptive anaerobic denitrification (Tata et al., 2017). |
| PhrD |
73nt |
PAO1_785,498-785,570 |
Yes |
RhlR mRNA |
Overexpression of PhrD increases the level of RhlR transcript, rhamnolipid and pyocyanin production; PhrD has a sequence specific promoting effect on RhlR transcripts without the involvement of any Pseudomonas specific proteins (Malgaonkar & Nair, 2019). |
| RhlS |
70nt |
PAO1_3889700-3899900 |
Yes |
fpvA mRNA |
Complementary pairing with fpvA mRNA base to regulate its translation; when entering the stable phase, RhlS accumulates and produces normal levels of C4-HSL by stimulating RhlI mRNA translation (Thomason et al., 2019). |
| Sr006 |
123nt |
PAO1_182,570-182,693 |
Yes |
pagL mRNA |
Positively regulates the expression of PagL, reduces its pro-inflammatory properties and leads to polymyxin resistance (Zhang et al., 2017). |
| Sr0161 |
247nt |
PAO1_184,211–184,458 |
Yes |
oprD mRNA |
Base pairing with 5 ’UTR of OprD results in increased bacterial resistance to meropenem. Inhibits T3SS after interacting with exsA mRNA (Zhang et al., 2017). |
| SrbA |
239nt |
PA14_2,977,373–2,977,611 |
Not describe |
With a large number of different mRNA targets |
SrbA plays an important role in biofilm formation and pathogenicity of P. aeruginosa (Gill et al., 2018; Taylor et al., 2017). |
| sRNA52320 |
Not describe |
Not describe |
Not describe |
Host mRNAs |
sRNA52320 is rich in OMV (outer membrane vesicle), which can inhibit the secretion of IL-8 and KC cytokines induced by LPS and OMV, and reduce the infiltration of neutrophils in mouse lung. It participates in pathogen-host interaction and reduces host immune response (Koeppen et al., 2016). |
