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. 2022 Jun 22;7(12):e153944. doi: 10.1172/jci.insight.153944

Figure 6. DCA recovers sepsis-induced anorexia and reprograms systemic fuel utilization.

Figure 6

(A) Cumulative food intake of sham, CLP, and CLP + DCA over 30 hours (n = 3 sham; 4 CLP; 7 CLP + DCA). (B) Heatmap depiction of average log2 fold change in carbohydrate levels measured by UPLC-MS/MS from plasma of sham, CLP, and CLP + DCA 30 hours after surgery (n = 3 sham; 4 CLP; 7 CLP + DCA). (C) Relative fatty acid levels measured by UPLC-MS/MS from plasma of sham, CLP, and CLP + DCA 30 hours after surgery (n = 7 sham; 10 CLP; 10 CLP + DCA). (D) RER of sham, CLP, and CLP + DCA for 30 hours (n = 3 sham; 4 CLP; 7 CLP + DCA). Average RER for (E) 12-hour dark cycle, (F) 12-hour light cycle, and (G) 3-hour dark cycle. (H) Total energy expenditure (TEE) of sham, CLP, and CLP + DCA for 30 hours (n = 3 sham; 4 CLP; 7 CLP + DCA). Average EE for (I) 12-hour dark cycle, (J) 12-hour light cycle, and (K) 3-hour dark cycle. *P < 0.05, **P < 0.01, ***P < 0.001. Statistical significance was determined using 1-way ANOVA.