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. 2022 Jun 22;7(12):e158754. doi: 10.1172/jci.insight.158754

Figure 8. Palbociclib reduces STAT3 activation and IL-1β expression in CKD injury models.

Figure 8

(A and B) Cortical tissue from mice injured by UniNx/AngII was immunoblotted for pSTAT3, total STAT3, and GAPDH for loading control and quantified. (C and D) Gene expression for IL-1β (Il1b) was measured in renal cortices of UniNx/AngII-injured and adenine nephropathy-treated mice with qPCR using Gapdh as a housekeeping gene. (E and F) NGAL (Lcn2) and PDGF-β (Pdgfb) were measured in renal cortices of UniNx/AngII injured mice. *P < 0.05 using the 2-tailed Student’s t test. NGAL, neutrophil gelatinase-associated lipocalin; PDGF-β, platelet-derived growth factor β.