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. 2022 Jun 22;7(12):e148990. doi: 10.1172/jci.insight.148990

Figure 2. Clustering identifies major immune constituents.

Figure 2

(A) UMAP clustering at a resolution of 0.1 of immune constituents from n = 3 spontaneous QPP mice, showing macrophages, microglia, antigen-presenting-like cells (APCs), and neutrophils with 9 principal components (PCs), determined by elbow plot. (B) UMAPs of immune constituents from n = 3 implanted QPP7 mice, showing neutrophils, microglia/macrophages, T cells/NK cells, APCs, and lytic myeloid cells with 9 PCs, determined by elbow plot. (C) Comparison of the implanted and spontaneous QPP tumor clusters showing neutrophils, microglia/macrophages, T cells/NK cells, APCs, and lytic myeloid cells with 9 PCs, determined by elbow plot. (D) UMAPs of immune constituents from n = 15 patients with glioma, showing clusters of polarized microglia, APC microglia, APCs, T cells, macrophages, NK cells, neutrophils, DCs, ILCs, immature myeloid cells, and B cells with 20 PCs, determined by elbow plot.