Table 2.
Parameters from ROC curves of circulant immune mediators as predictors of AKI or AKI + death in COVID-19 hospitalized patients at “Early” timepoint.
| Parameters | AUC | 95% CI | Cut-off | Sens (%) | Spec (%) | P-value |
|---|---|---|---|---|---|---|
| A) No AKI vs. AKI | ||||||
| CXCL-10 | 0.739 | 0.627–0.853 | >314.2 | 72.7 | 63.8 | 0.0003 |
| IFN-γ | 0.722 | 0.602–0.842 | >14.1 | 70.9 | 63.4 | 0.001 |
| IL-10 | 0.717 | 0.599–0.835 | >3.15 | 71.9 | 65.9 | 0.001 |
| IL-1Ra | 0.713 | 0.594–0.831 | >349 | 69.7 | 63.8 | 0.001 |
| CCL-2 | 0.703 | 0.584–0.822 | >22.0 | 63.6 | 61.7 | 0.002 |
| CXCL-8 | 0.682 | 0.563–0.802 | >17.9 | 54.5 | 80.5 | 0.006 |
| IL-6 | 0.681 | 0.560–0.802 | >1.75 | 63.6 | 65.9 | 0.006 |
| B) AKI + survival vs. AKI + death | ||||||
| CCL-2 | 0.879 | 0.764–0.994 | >21.5 | 83.3 | 80.0 | 0.0006 |
| CXCL-10 | 0.841 | 0.694–0.988 | >341.6 | 79.2 | 70.0 | 0.002 |
| IL-6 | 0.752 | 0.591–0.913 | >2.7 | 75.0 | 70.0 | 0.02 |
| CXCL-8 | 0.725 | 0.532–0.917 | >15.4 | 66.7 | 70.0 | 0.04 |
AUC = area under the curve; CI = confidence interval; sens = sensitivity; spec = specificity.