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. 2022 Feb 8;40(11):2510–2521. doi: 10.1002/jor.25286

Figure 3.

Figure 3

Loss of Metrnl expression does not affect skeletal development. Metrnl+/−  × Metrnl+/− breeding pairs were used to generate wildtype, haplotype, and knockout progeny. Skeletons and femurs of (A) E15.5 mice and (B) E18.5 mice underwent whole mount staining (Alizarin red, bone; Alcian blue, cartilage). Relative femur length and relative mineralization length of E15.5 pups (C,D) and E18.5 pups (E,F) was measured. n = 5, data are expressed as mean ± 95% confidence interval [Color figure can be viewed at wileyonlinelibrary.com]