FIGURE 13.

Late‐acting specification of the fission zone. This model is informed by mutant (loss‐of‐function) and GFP‐localization data. Prior to FZ induction (left panel) the posterior CdaA‐Cyclin E/CDK circuit (CDK not yet identified), represses fission zone formation (red). Later, the anterior late Hippo‐circuit (CdaI‐driven) is expressed, and it inhibits FZ assembly within the anterior hemi‐cell (blue). The CdaA and CdaI zones exclude each other. The FZ assembles at the boundary between the CdaI and the CdaA‐domains. Later, the CdaA/CdaI boundary may also contribute to assembly of the early Hippo circuit components just anterior to the fission zone which may in turn promote establishment of CdaA in the anterior hemicell during the next generation