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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Chem Rev. 2022 Jan 25;122(14):12207–12243. doi: 10.1021/acs.chemrev.1c00915

Figure 38.

Figure 38.

Cartoon of the LO active site pocket, illustrating the role of steric effects (Ala vs. Gly) and substrate orientation (CH3 first – top, COOH first – bottom) on LO site selectivity for substrate C-H activation (see substrate radical) and subsequent peroxidation via sterically directed attack of O2 (red). Adapted from ref 122. Copyright 2004 National Academy of Sciences.