Fig. 5.

Parkinsonian beta activity in the subthalamic nucleus is suppressed with deep brain stimulation. Local field potentials (LFP) can be recorded directly through implanted DBS electrodes (A). In the medication and stimulation OFF state, the amplitude of beta oscillatory activity is increased (A left) and suppressed with deep brain stimulation (DBS) switched ON (right). Recently, the dose dependence of beta and DBS could be revealed through sensing enabled implantable devices (B; Feldmann et al., 2021a, Feldmann et al., 2021a).