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. 2022 Jul 25;7:82. doi: 10.1038/s41541-022-00508-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Six-week-old offspring of naïve (red) or of immunized and subsequently infected with SARS-CoV-2-S^D614G (green) K18-hACE2 mice were challenged intranasally with 3 × 10⁴ TCID₅₀ SARS-CoV-2-S^D614G. a Determination of virus neutralization titers (ND₅₀) in serum of offspring 1 week before and 5 days after challenge infection. b Body weight at the indicated times pi. c Determination of infectious SARS-CoV-2 titers in lung and brain tissue homogenates 5 days pi. Geometric means and geometric SD are indicated. Statistically significant differences were determined by the two-way ANOVA test (a) or by the two-tailed unpaired Student’s t test (c) (*p < 0.05; **p < 0.005, ****p < 0.0001).