TABLE 2.

Co-morbidity of SAG with different disorders.

Body part	Disorders	Streptococcus species	Total number of		Description of the study	References
			Isolates	Patients
Head and neck	Intracranial abscess	S. anginosus	1	1	Multiple intracranial abscesses in a previously well individual	Kirkman et al., 2012
	Brain abscess	S. intermedius	19	39	Diagnosis was secured in 39 patients, among which the majority were SAG (69%) with a predominance of S. intermedius (70%).	Darlow et al., 2020
		S. intermedius	2	2	Predisposing condition was a paranasal sinusitis of the frontal and ethmoidal sinuses	Yamamoto et al., 1999
		S. anginosus	1	1	Case represents a frontal lobe abscess caused by contiguous spread of S. anginosus from a frontal sinus infection	Esplin et al., 2017
	Peritonsillar abscess	S. constellatus	13	65	67 aerobic isolates from peritonsillar abscess 55 were classified as Streptococcus spp. with the SAG as the most common type (20 isolates).	Hidaka et al., 2011
		S. intermedius	7
	Orofacial abscesses	S. intermedius	19	198	The strains of SAG were encountered most frequently (81% of infections) as part of a mixed growth.	Wilson, et al., 1995
		S. constellatus	16
		S. anginosus	8
		S. anginosus	1	6	Septic cavernous sinus thrombosis and orbital cellulitis	Branson et al., 2019
	Lemierre’s syndrome	S. anginosus	1	1	Case report	Santos et al., 2020
Pulmonary disorders	Lung abscess	S. constellatus	21	72	Species belonging to the SAG accounted for the majority 68% of isolates	Jerng et al., 1997
		S. intermedius	17
	Pleural empyema	S. intermedius	16	30	S. intermedius was significantly more common in patients with lung abscess with pleural effusion	Noguchi et al., 2015
		S. constellatus	11
		S. anginosus	3
	Pneumonia	S. constellatus	16	31	Empyema was observed in patients with multiple bacteria	Hirai et al., 2016
		S. anginosus	13
		S. intermedius	2
		S. intermedius	1	1	Immunocompetent patient	Hannoodi et al., 2016
Cardiovascular diseases	Pericarditis	S. anginosus	4	4 case reports	Pneumopericardium secondary to gastropericardial fistula, purulent pericardial effusion secondary to transdiaphragmatic rupture of pyogenic liver abscess	Maves et al., 2017; Cai, 2020; Prateepchaiboon et al., 2020; Ono et al., 2021
		S. intermedius	3	3 case reports	The first reported case of purulent pericarditis with S. intermedius in a child, patient with the history of bronchiectasis and pneumonia	Presnell et al., 2014; Tigen et al., 2015; Khan et al., 2018
	Endocarditis	S. anginosus	6	377	All SAG isolates were identified as S. anginosus	Woo et al., 2004
		S. constellatus	11	11	Infection tends to be complicated with a high frequency of septic embolization	Yoshino et al., 2013
Liver disorders	Liver abscess	S. intermedius	11	11 case reports	Bacteremia and liver abscess following a routine dental infections, infection associated with gastrointestinal stromal tumor, diverticulitis of the colon, adenocarcinoma of the colon, acute cholangitis sump syndrome, chronic granulomatous disease	Hiura et al., 2000; Millichap et al., 2005; Wagner et al., 2006; Neumayr et al., 2010; Falcone et al., 2012; Livingston and Perez-Colon, 2014; Benou et al., 2016; Mayor et al., 2016; Parthvi et al., 2017; Reddy et al., 2018; Hanna et al., 2020
		S. constellatus	5	5 case reports	Diverticulitis of the sigmoid colon and subsequent hematogenous spread of bacteria, infection associated with gastric adenocarcinoma	Akuzawa et al., 2017; Dsouza et al., 2019; Wong, et al., 2019; Chrastek et al., 2020; Navarrete et al., 2020