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. 2022 Jul 8;12:945924. doi: 10.3389/fcimb.2022.945924

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Copyright © 2022 Lyons, Gabriela, Tham and Dietrich

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Crystal structures of the 6-cysteine proteins of P. falciparum in complex with another 6-cysteine protein or antibody fragments. (A) Crystal structure of the hetero-dimeric complex of Pf12 and Pf41 with indicated D1 and D2 domains and the inserted domain-like region (ID) of Pf41. (B) 6-cysteine proteins bound to nanobodies. Pf12 bound to Nb G7 (left), Pf12p bound to Nb B9 (middle) and Nb D9 (right). (C) 6-cysteine protein domains bound to Fab and single-chain fragment variable (scFv) regions. Pfs230 D1 in complex with scFv of LMIV230-01 (left) and Fab of 4F12 (middle). Pfs48/45 D3 bound to Fab of 85RF45.1 (right).