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. 2022 Jul 8;9:929776. doi: 10.3389/fnut.2022.929776

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Copyright © 2022 Guo, Guan, Duan, Ren, Zhang, Xu, Shi, Wang, Lu, Zhang, Xu, Li and Geng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Goji maintained the gut microenvironment and modulated the overall structure of gut microbiota. (A) AB–PAS staining and immunohistochemical analysis of the expression of MUC2 of colon section. Scale bars, 100 μm. (B) The relative expression of Claudin1 in the colon. (C) quantification of cecal acetic acid. (D) quantification of butyric acid. (E) quantification of isovaleric acid. (F) Shannon index of microbiota; (G) Simpson index of microbiota. (H) principal-coordinate analysis (PCoA) plot at D0 based on unweighted UniFrac distance. Each point represents each sample. (I) PCoA plot at D14. (J) PCoA plot at D15. F–J, n = 8. Data are shown as mean ± SEM, and statistical significance is assessed by one-way ANOVA corrected for multiple comparison by Tukey's test. *p-value < 0.05.