Table 1.

Top ten most differential enriched miRNAs in NHEM and NHEM-derived EVs.

miRNA	RPM cells	RPM EVs	log2 fold enrichment	adj. p-value
enriched in NHEM EVs
hsa-miR-486-5p	27.73	7920.17	8.16	0.0072
hsa-miR-223-3p	1.78	345.59	7.60	0.0051
hsa-miR-451a	26.06	3113.14	6.90	0.0333
hsa-miR-122-5p	24.25	2310.82	6.57	0.0134
hsa-miR-335-5p	8.16	718.49	6.46	0.0366
hsa-miR-9-3p	7.55	516.16	6.10	0.0058
hsa-miR-23a-5p	14.38	918.05	6.00	0.0186
hsa-miR-92a-1-5p	20.84	900.46	5.43	0.0357
hsa-miR-125b-1-3p	17.48	661.36	5.24	0.0204
hsa-miR-296-3p	14.21	446.87	4.97	0.0124
enriched in NHEM cells
hsa-miR-513b-5p	1044.94	221.92	-2.24	0.0121
hsa-miR-506-3p	909.44	173.27	-2.39	0.0155
hsa-miR-513a-5p	1976.22	351.60	-2.49	0.0277
hsa-miR-508-5p	780.43	125.31	-2.64	0.0150
hsa-miR-1296-5p	20.71	2.79	-2.89	0.0134
hsa-miR-508-3p	7454.42	867.43	-3.10	0.0232
hsa-miR-514a-3p	2596.72	273.98	-3.24	0.0146
hsa-miR-509-5p	396.49	36.52	-3.44	0.0267
hsa-miR-514a-5p	227.58	17.64	-3.69	0.0056
hsa-miR-146a-3p	72.94	3.49	-4.38	0.0430