Table 2.

Top ten most differential enriched miRNAs in melanoma cells and melanoma-derived EVs.

miRNA	RPM cells	RPM EVs	log2 fold enrichment	adj. p-value
enriched in melanoma EVs
hsa-miR-1246	12.88	40442.23	11.62	0.0418
hsa-miR-7704	7.54	1846.05	7.94	0.0379
hsa-miR-493-5p	4.02	292.05	6.18	0.0398
hsa-miR-369-3p	13.08	577.75	5.46	0.0349
hsa-miR-941	8.27	169.51	4.36	0.0317
hsa-miR-143-3p	108.13	1662.16	3.94	0.0353
hsa-miR-30c-1-3p	18.19	210.16	3.53	0.0468
hsa-miR-3615-3p	18.33	146.52	3.00	0.0393
hsa-miR-514a-5p	1.53	11.03	2.85	0.0375
hsa-miR-29c-3p	20.32	104.19	2.36	0.0468
enriched in melanoma cells
hsa-miR-130b-5p	739.48	391.29	-0.92	0.0342
hsa-miR-23b-5p	106.32	26.46	-2.01	0.0405
hsa-miR-3605-3p	110.25	27.41	-2.01	0.0413
hsa-miR-148a-5p	42.92	7.19	-2.58	0.0406
hsa-miR-1285-3p	8.54	n.d.	n.c.	n.c.
hsa-miR-548a-3p	15.34	n.d.	n.c.	n.c.
hsa-miR-3176-3p	28.49	n.d.	n.c.	n.c.
hsa-miR-4458	74.81	n.d.	n.c.	n.c.

n.d., not detected; n.c., not calculated.