Figure 1.

Schematic overview of DADA2 alterations in immune cells and the described related clinical signs and laboratory findings. DADA2 is associated with a wide variety of clinical manifestations. Here is a summary of clinical and immunological features, grouped in the two branches of the immune system; innate (A) and adaptive (B). LDG, Low Density Granulocytes; Treg, regulatory T cells; cTfh, circulating Tfh; MAIT, mucosal-associated invariant T; MAS, macrophage activation syndrome; ALPS; Autoimmune Lymphoproliferative Syndrome.