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. 2022 Jul 11;13:848508. doi: 10.3389/fphys.2022.848508

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Copyright © 2022 Liu, Wang, Chang, Bhetuwal, Bhattarai and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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System-wide analysis of the metabolic pathways of ICP patients. (A) Metabolic pathway analysis of differential metabolites by using MetaboAnalyst. The size of the nodes shows the number of matched metabolites, the color of the nodes represents p value of the enrichment analysis. (B–D) Quantitative analysis of bile acids, cholesterol sulfate, bilirubin; fatty acids, lipids, and sterol hormones in the two groups, respectively. The Mann–Whitney U test is performed, ^* p < 0.05, ^** p < 0.01 vs. controls. (E,F) Pearson correlation analysis of estrone sulfate with TBA and neonatal weights in ICP patients, respectively. The 95% confidence interval for the linear regression is represented by the gray area.