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. 2022 Jul 11;12:907239. doi: 10.3389/fcimb.2022.907239

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Copyright © 2022 Zhong, Chen, Wang, Shao, Zhou and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of gut microbiota compositions in HC and moderate and severe MDD patients. (A) Relative abundances of gut microbiota at the genus level in MDD patients and HC. (B) OPLS-DA model showed that there was only a small overlap between HC and moderate MDD patients, suggesting the divergent microbial changes between the two groups; (C) differential genera responsible for discriminating moderate MDD patients from HC; (D) OPLS-DA model showed that there was only a small overlap between HC and severe MDD patients, suggesting the divergent microbial changes between the two groups; (E) differential genera responsible for discriminating severe MDD patients from HC. HC, healthy controls; MDD, major depressive disorder; Fae, Faecalibacterium; Vic, Victivallis; Meg1, Megamonas; Pyr, Pyramidobacter; Hyd, Hydrogenoanaerobacterium; Pre, Prevotella; Kle, Klebsiella; Ace, Acetanaerobacterium; But, Butyricimonas; Ali, Alistipes; Cop, Coprobacillus; Ana1, Anaerococcus; Act, Actinomyces; Eub, Eubacterium; Par1, Parabacteroides; Psy, Psychrobacter; Odo, Odoribacter; Ent1, Enterococcus; Ent2, Enterorhabdus; Cor, Corynebacterium; Ana2, Anaerofustis; All, Allisonella; Por, Porphyromonas; Bar, Barnesiella; Ols, Olsenella; Dor, Dorea; Oxa, Oxalobacter; Egg, Eggerthella; Sla, Slackia; Fla, Flavonifractor; Pep, Peptoniphilus; Bla, Blautia; Ana3, Anaerotruncus; Par2, Parvimonas; Gor, Gordonibacter; Col, Collinsella; Lac1, Lactococcus; Sut, Sutterella; Tur, Turicibacter; Meg2, Megasphaera; Bil, Bilophila; Lac2, Lactobacillus; Bac, Bacteroides; Ana, Anaeroglobus.