Table 3.
Differential genera responsible for discriminating severe MDD patients from HC.
| Genus | VIP | FC | Phylum |
|---|---|---|---|
| Anaeroglobus | 1.91 | 0.04 | Firmicutes |
| Turicibacter | 1.40 | 0.09 | Firmicutes |
| Lactobacillus | 1.68 | 0.11 | Firmicutes |
| Acetanaerobacterium | 1.61 | 0.16 | Firmicutes |
| Peptoniphilus | 1.66 | 0.16 | Firmicutes |
| Eubacterium | 1.75 | 0.30 | Firmicutes |
| Anaerotruncus | 1.71 | 0.35 | Firmicutes |
| Porphyromonas | 1.37 | 0.39 | Bacteroidota |
| Bilophila | 2.55 | 0.40 | Desulfobacterota |
| Parabacteroides | 2.14 | 0.41 | Bacteroidota |
| Butyricimonas | 1.92 | 0.43 | Bacteroidota |
| Flavonifractor | 2.42 | 0.43 | Firmicutes |
| Megasphaera | 1.00 | 0.45 | Firmicutes |
| Alistipes | 1.83 | 0.60 | Bacteroidota |
| Odoribacter | 1.49 | 0.65 | Bacteroidota |
| Collinsella | 1.47 | 0.66 | Actinobacteriota |
| Blautia | 1.58 | 0.80 | Firmicutes |
| Bacteroides | 1.55 | 0.90 | Bacteroidota |
| Eggerthella | 1.23 | 0.92 | Actinobacteriota |
| Faecalibacterium | 1.41 | 1.37 | Firmicutes |
| Dorea | 1.53 | 1.55 | Firmicutes |
| Hydrogenoanaerobacterium | 1.15 | 1.98 | Firmicutes |
| Klebsiella | 1.37 | 2.28 | Proteobacteria |
| Sutterella | 1.24 | 2.97 | Proteobacteria |
| Victivallis | 1.14 | 6.39 | Verrucomicrobiota |
| Pyramidobacter | 1.27 | 36.23 | Synergistota |
| Lactococcus | 1.03 | 37.70 | Firmicutes |
HC, healthy controls; MDD, major depressive disorder; VIP, important variables on the projection; FC, fold change, compared to HC. >1.0 and <1.0 indicated significantly lower and higher levels, respectively, in MDD patients.