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. 2022 Jul 11;12:948014. doi: 10.3389/fcimb.2022.948014

Figure 2.

Figure 2

PRNT ND50 correlation between WT and Delta or Omicron variant. (A–F) Log10 PRNT ND50 among strains was compared using a linear regression model. When interpreting the correlation coefficient, R 2 ≥ 0.7 was considered a strong correlation, R 2 ≥ 0.4 a moderate correlation, and R 2 < 0.47 a week correlation (Schober et al., 2018). (A–C) WT and Delta variants show a consistently strong correlation regardless of vaccination groups. (D–F) Linear correlation between PRNT ND50 against WT and Omicron was also noticed, but the coefficient of determination was lower than that between WT and Delta (moderate correlation). Homologous boosting included sera after BNT-BNT, BNT-BNT-BNT, and ChAd-ChAd, while heterologous boosting included sera after ChAd-BNT, ChAd-BNT-BNT, and ChAd-ChAd-BNT. PRNT, plaque reduction neutralizing test; ND50, 50% neutralization dose; WT, wild type; ChAd, ChAdOx1 vaccine; BNT, BNT162b2 vaccine.