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. 2022 Jul 11;13:906662. doi: 10.3389/fgene.2022.906662

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Copyright © 2022 Pavlenko, Ruengeler, Engel and Poepsel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) KDM5 demethylases remove methyl groups from H3K4 in a sequential manner, using the dioxygenase activity of their catalytic JmjC domain. 2-Oxoglutarate (2-OG) is decarboxylated to succinate. Formaldehyde, one of the products of demethylation, is commonly detected in quantitative assays of JmjC demethylase activity. (B) Domain organization of the four human KDM5 demethylases and the Drosophila KDM5 homolog Lid. ZF = C5HC2 Zinc Finger. Numbers correspond to the amino acid numbering of each KDM5 protein.