Table 2.

Future areas of study in the management of advanced heart failure in women.

Areas of equipoise in the management of advanced heart failure in women	Potential areas of future research
Hemodynamic instability	Identify sex-specific cutoffs that indicate hemodynamic compromise in men and women
Biomarker derangements	Explore the validity of sex-specific cutoffs for advanced heart failure prognostication
Exercise capacity	Investigate sex specific cut-offs in 6-min walk test, exercise duration and functional capacity
Frailty assessment	Explore the optimal strategy for frailty assessment among women with advanced heart failure
Waitlisting prior to heart transplant	Identify the optimal waitlist strategy for female patients in the pre-transplant period
Chronic inotrope use	Impact of chronic inotropes on sex-based clinical outcomes
Palliative care	Explore a sex-specific approach to the use of palliative care interventions
Temporary mechanical circulatory support	Evaluate sex-specific differences in the utilization and outcomes of temporary mechanical circulatory support
Anticoagulation strategy in LVAD	Explore optimal anticoagulation strategies in male and female LVAD patients
Referral for advanced therapies	Evaluate the role of a sex-specific risk stratification strategy in referrals for advanced cardiac therapies
Allocation of advanced therapies	Evaluate impact of interventions aimed at reducing inequities in allocation of advanced cardiac therapies

LVAD, left ventricular assist devices.