Table 5A.
Hospitalization as recurrent event analysis of the cohort according to the treatment arm.
| eGFR | <60 ml/min/1.73 m 2 | IRR RPM vs. UC | p -value | ≥60 ml/min/1.73 m 2 | IRR RPM vs. UC | p -value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RPM (N = 433) | UC (N = 445) | RPM (N = 332) | UC (N = 328) | |||||||||
| Number of patients with events | Weighted average (95% CI) | Number of patients with events | Weighted average (95% CI) | Number of patients with events | Weighted average (95% CI) | Number of patients with events | Weighted average (95% CI) | |||||
| CV hospitalizations (number of patients) | 171 (39.5%) |
175 (39.3%) |
0.9 | 81 (24.4%) |
94 (28.7%) |
0.4 | ||||||
| CV hospitalizations (sum of hospitalizations) | 274 | 0.70 (0.59, 0.83) |
327 | 0.82 (0.69, 0.96) |
0.86 (0.68, 1.08) |
0.2 | 134 | 0.40 (0.32, 0.50) |
153 | 0.46 (0.37, 0.57) |
0.86 (0.64, 1.17) |
0.3 |
| CV hospitalizations and all-cause death (number of patients) | 177 (40.9%) |
194 (43.6%) |
0.4 | 88 (26.5%) |
96 (29.3%) |
0.86 (0.63, 1.18) |
0.4 | |||||
| CV hospitalizations and all-cause death (sum of hospitalizations) | 318 | 0.87 (0.73, 1.04) |
398 | 1.09 (0.92, 1.28) |
0.80 (0.63, 1.02) |
0.07 | 147 | 0.45 (0.36, 0.56) |
167 | 0.52 (0.42, 0.64) |
0.86 (0.63, 1.18) |
0.4 |
| CV hospitalizations and CV death (number of patients) | 175 (40.4%) |
186 (41.8%) |
0.7 | 84 (25.3%) |
95 (29.0%) |
0.5 | ||||||
| CV hospitalizations and CV death (sum of hospitalizations) | 307 | 0.83 (0.70, 0.99) |
375 | 0.99 (0.84, 1.17) |
0.84 (0.66, 1.07) |
0.2 | 143 | 0.43 (0.34, 0.54) |
164 | 0.51 (0.41, 0.63) |
0.85 (0.62, 1.16) |
0.3 |
| HF hospitalizations and all-cause death (number of patients) | 119 (27.5%) |
156 (35.1%) |
0.02 | 45 (13.6%) |
67 (20.4%) |
0.02 | ||||||
| HF hospitalizations and all-cause death (sum of hospitalizations) | 214 | 0.61 (0.49, 0.76) |
304 | 0.88 (0.72, 1.07) |
0.70 (0.52, 0.94) |
0.02 | 66 | 0.21 (0.15, 0.28) |
101 | 0.32 (0.24, 0.42) |
0.64 (0.42, 0.97) |
0.04 |
| HF hospitalizations and CV death (number of patients) | 112 (25.9%) |
145 (32.6%) |
0.03 | 41 (12.3%) |
65 (19.8%) |
0.01 | ||||||
| HF hospitalizations and CV death (sum of hospitalizations) | 203 | 0.58 (0.47, 0.72) |
281 | 0.79 (0.64, 0.97) |
0.74 (0.55, 1.00) |
0.05 | 62 | 0.19 (0.14, 0.26) |
98 | 0.31 (0.24, 0.41) |
0.61 (0.40, 0.94) |
0.02 |
Number of patients mark the frequency of patients affected from hospitalizations, sum of hospitalizations marks the duration of hospitalizations. CI, confidence interval; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HF, heart failure; RPM, remote patient management; UC, usual care; IRR, incident rate ratio. p-value was calculated with a permutation test using individual observation time as weights.