Table 5.
Circular RNAs can regulate cell death pathways in oral cancer.
| Circular-RNAs | Expression | Cancer cell | Target of miRNA | Inhibition/Induction of Cell Death | Sample type | Note | Ref |
|---|---|---|---|---|---|---|---|
| circRNA_100533 | Down | OSCC | miR-933 | Induction of apoptosis | In vitro (CAL‐27 and SCC‐9 cell lines) | circRNA_100533 can induce apoptosis of OSCC cells by sponging miR‐933, and then regulating GNAS expression. | (107) |
| circBICD2 | Up | OSCC | miR-149-5p | Inhibition of apoptosis | Human (Tongue, n= 15; Buccal, n= 5; and gingival, n= 6), In vitro (SCC25 and CAL27 cells) | IGF2BP1 inhibits the apoptosis of OSCC cells by regulating the miR-149-5p/IGF2BP1 axis. | (108) |
| circFNDC3B | Up | OSCC | miR-520d-5p | Inhibition of apoptosis | In vitro (CAL27 and SCC15 cells) | Downregulation of circFNDC3B promotes apoptosis of OSCC cells by regulating the miR-520d-5p/SLC7A11 axis | (109) |
| circ_0109291 | Up | OSCC | – | Inhibition of apoptosis | Human (OSCC tissue, n= 51), In vitro (CAL27 and SCC4 cells) | Downregulation of circ_0109291 induces apoptosis of OSCC cells. | (110) |
| circ_0002203 | Down | OSCC | – | Induction of apoptosis | Human (OSCC tissue, n=40), In vitro (CAL27 and SCC15 cells) | Overexpression of circ_0002203 promotes apoptosis of OSCC cells. | (111) |
| circ_0055538 | Down | OSCC | The p53/Bcl-2/caspase signaling pathway | Induction of apoptosis | Human (OSCC tissue, n= 44), In vitro (CAL27 and SCC9 cells) | Overexpression of circ_0055538 induces the apoptosis of OSCC cells by regulating the p53/Bcl-2/caspase signaling pathway. | (112) |
| circ_0007059 | Down | OSCC | – | Induction of apoptosis | Human (OSCC tissue, n=52), In vitro (CAL27 and SCC15 cells) | Overexpression of circ_0007059 induces the apoptosis of OSCC cells maybe by remodulation of AKT/mTOR pathway. | (113) |
| circ_009755 | Down | OSCC | – | Induction of apoptosis | Human (OSCC tissue, n=8), In vitro (CAL27 and SCC15 cells) | Decrease the expression level of circ_009755 suppresses the apoptosis of OSCC cells. | (114) |
| circATRNL1 | Down | OSCC | miR-23a-3p | Induction of apoptosis | Human (OSCC, tissue, n= 48), In vitro (HSC3 and SCC25 cells) | Overexpression of circATRNL1 help to improved sensitivity of OSCC cells to radiotherapy by promotes apoptosis through sponging miR-23a-3p. | (115) |
| circ_0033144 (CircBCL11B) | Up | OSCC | miR-579/LASP1 axis. | Inhibition of apoptosis | Human (OSCC, tissue, n= 50), In vitro (CAL27 and SCC15 cells) | Downregulation of cirCBCL11B promotes the apoptosis of OSCC cells by regulating miR-579/LASP1 axis. | (116) |
| CircSPATA6 | Down | OSCC | miR-182/TRAF6 axis | Induction of apoptosis | Human (OSCC, serum, n= 46), In vitro (CAL27 and SCC9 cells) | CircSPATA6 promotes apoptosis of OSCC cell by regulating the miR-182/TRAF6 axis. | (117) |
| Circ-BICD2 | Up | OSCC | miR-296-5p | Inhibition of apoptosis | Human (OSCC tissue, n= 35), In vitro (CAL27 and SCC9 cells) | circ-BICD2 can promote apoptosis of OSCC cells might by the regulating the miR-296-5p/TAGLN2 axis. | (118) |
| Circ-ITCH | Down | OSCC | miR-421 | Induction of apoptosis | Human (OSCC tissue, n=57), In vitro (SCC6 and HN4 cells) | Overexpression of circ-ITCH promotes apoptosis of OSCC cells through regulating miR-421/PDCD4 axis. | (119) |
| Circ-PVT1 | Up | OSCC | – | Induction of apoptosis | Human (OSCC tissue, n=30), In vitro (SCC4 and CAL27 cells) | circ-PVT1 promotes apoptosis of OSCC cells. | (120) |
| Circ-KIAA0907 | Down | OSCC | miR-96-5p | Induction of apoptosis | Human (OSCC tissue, n=59), In vitro (HSC6 and OECM1 cells) | circ-KIAA0907 induces apoptosis of OSCC cells through regulating the miR-96-5p/UNC13C axis. | (121) |
| circKRT1 | Up | OSCC | miR‐495‐3p | Inhibition of apoptosis | Human (OSCC tissue, n=50), In vitro (Cal‐27 and HSC‐3) | Downregulation of circKRT1 inhibits the apoptosis of CD8+ T cells by regulating by the miR‐495‐3p/PDL1 axis and suggested that suppresses activity of CD8+ T‐cell to induces immune evasion of OSCC cells. | (122) |
| circ_0000140 | Down | OSCC | miR-31 | Induction of apoptosis | Human (OSCC tissue, n=56), In vitro (Cal-27, HSC-3 and HOK cells) | circ_0000140 promotes apoptosis of OSCC cells by regulation of miR-31/LATS2 axis. | (123) |
| circRNA_043621 | Up | OSCC | – | Inhibition of apoptosis | Human (OSCC tissue, n= 23), In vitro (TSCC1 cell) |
The circRNA_043621 downregulation leads to induction of apoptosis in OSCC cells. | (124) |
| circRNA_102459 | Down | OSCC | – | Induction of apoptosis | Human (OSCC tissue, n= 23), In vitro (TSCC1 cell) |
The circRNA_102459 overexpression leads to induction of apoptosis in OSCC cells. | (124) |
| Circ-HIPK3 | Up | OSCC | miR-381-3p | Inhibition of apoptosis | In vitro (SCC-4 and SCC-9 cells) | circ-HIPK3 inhibits apoptosis of OSCC cells through regulating miR-381-3p/YAP1 axis. | (125) |
| CircRNA_10103 | Down | OSCC | – | Induction of apoptosis | In vitro (OECM1 and HSC3 cells) | Overexpression of circRNA_10103 induces apoptosis of OECM1 and HSC3 cells. | (126) |
| circ_0001742 | Up | TSCC | miR-431-5p | Inhibition of apoptosis | Human (TSCC tissue, n= 30), In vitro (CAL27 and SCC4 cells) |
circ_0001742 inhibits apoptosis of TSCC cells by regulating the miR-431-5p/ATF3 axis. | (127) |
| circ_0005379 | Down | OSCC | – | Induction of apoptosis | Human (OSCC tissue, n= 37), In vitro (SCC25 and CAL27 cells) |
Overexpression of circ_0005379 induces apoptosis of OSCC cells might by regulating the EGFR pathway. | (128) |
| circ_0011946 | Up | OSCC | miR-216a | Inhibition of apoptosis | Human (OSCC tissue, n= 30), In vitro (SCC25 and CAL27 cells) |
Downregulation of expression level of circ_0011946 induces apoptosis of OSCC cells by the regulation of the miR-216a-5p/BCL2L2 axis. | (129) |
| Circ_0001461 | Up | OSCC | miR-145 | Inhibition of apoptosis | Human (OSCC tissue, n= 20), In vitro (CAL-27 and KB cells) |
Circ_0001461 suppresses apoptosis of OSCC cells by regulating miR-145/TLR4/NF-κB axis. | (130) |
| circCDR1as | Up | OSCC | miR-876-5p | Induction of autophagy and inhibition of apoptosis | Human (OSCC tissue), In vitro (OSCC cells) |
Upregulation of circCDR1as levels induces autophagy, and inhibits apoptosis in OSCC cells by targeting miR-876-5p. | (131) |
| circHIPK3 | Up | OSCC | miR-637 | Inhibition of apoptosis | Human (OSCC tissue, n= 40), In vivo (mice) In vitro (Tca8113 and SCC-9 cells) |
CircHIPK3 inhibits apoptosis of OSCC cells through regulating the miR-637. | (132) |
| circDHTKD1 | Up | OSCC | miR-326 | Inhibition of apoptosis | Human (OSCC tissue, n= 56), In vitro (SCC9 and Cal27 cells) |
circDHTKD1 inhibits apoptosis of OSCC cells by targeting miR-326 | (133) |
| circ_0005623 | Human (OSCC tissue, n= 56), In vitro (SCC-9 and CAL-27 cells). |
||||||
| Circ_0002141 | Up | OSCC | Inhibition of apoptosis | Human (OSCC tissue, n= 52), In vitro (OSCC cells) |
Circ_0002141 inhibits apoptosis of OSCC cells by regulating miR-1231/EGFR axis | (134) | |
| circ_0005379 | Down | OSCC | miR-17-5p | Induction of apoptosis | Human (OSCC tissue), In vitro (SCC15 cells) |
Overexpression of circ_0005379 promotes apoptosis of OSCC cells by regulating the miR-17-5p/ACOX1 axis. | (135) |
| circ‐PKD2 | Down | OSCC | miR‐204‐3 | Induction of apoptosis | Human (OSCC tissue, n= 56), In vitro (SCC15 cells) |
circ‐PKD2 induces apoptosis of OSCC cell by suppressing of miR‐204‐3 activity. | (136) |
| circ_0001971 circ_0001874 | – | OSCC | – | Inhibits of apoptosis | In vitro (SCC9 cells) | Upregulation of circ_0001971 and circ_0001874 synergistically inhibits apoptosis of OSCC cells. | (137) |
| Circ_0001971 | Up | OSCC | miR-194 and miR-204 | Inhibits of apoptosis | Human (OSCC tissue, n= 50), In vitro (CAL-27 and SCC9 cells) | Circ_0001971 inhibits apoptosis of OSCC by regulating miR-194 and miR-204. | (138) |
| Circ_0109291 | Up | OSCC | miR-188-3p | Inhibits of apoptosis | Human (OSCC tissue, n= 60), In vitro (CAL-27/DDP and UM1/DDP cells) | Circ_0109291 was overexpressed in Cisplatin-resistant OSCC tissues and cells. Downregulation of circ_0109291 promotes apoptosis of OSCC cells by regulating the miR-188-3p/ABCB1 axis. |
(139) |
| circ_0000745 | Up | OSCC | miR-488 | Inhibition of apoptosis | Human (OSCC tissue, n= 64), In vitro (Cal-27 and SCC9 cells) | circ_0000745 inhibits apoptosis of OSCC cells by regulating expression level of miR-488/CCND1. | (140) |
| Circ-SCMH1 | Up | OSCC | miR-338-3p | Inhibition of apoptosis | Human (primary OSCC tissue, n= 62), In vitro (SCC-15/DDP and CAL-27/DDP) |
Circ-SCMH1 was overexpressed in Cisplatin-resistant OSCC tissues and cells. Circ-SCMH1 contribute to oral cancer development by inhibition of apoptosis in OSCC cells through regulating miR-338-3p/LIN28B. |
(141) |