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. 2022 Jul 11;12:899987. doi: 10.3389/fonc.2022.899987

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Copyright © 2022 Wang, Lin, Li, Cheng, Sun, Shao, Yang, Zhang, Feng, Gao, Gao and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FASN is positively correlates with USP13. (A, B) Representative images (A) of IHC staining for FASN protein on tissue microarray (TMA) composed of SCLC tumor specimens (T) with their adjacent normal tissues (N). IHC score (B) was calculated. Scale bars: 100 μm. Data represent the means ± SD of samples. Two-tailed student’s t-test was used. ***p < 0.001. (C) FASN expression levels are shown in SCLC patients of different cancer stages. Data represent the means ± SD of samples. Two-tailed student’s t-test was used. ***p < 0.001. (D) Kaplan-Meier plots of the overall survival time of 90 SCLC patients with low or high expression levels of FASN. p values are calculated using a log-rank test (two-tailed). (E) The correlation between USP13 and FASN expression in an SCLC tissue microarray was analyzed using a two-tailed Pearson correlation coefficient.