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Hazard ratios of flares defined as an increase of Psoriasis Area and Severity Index (PASI) ≥ 3 or PASI ≥ 5 for different response groups compared with PASI = 0. The partly adjusted model included adjustment for age, sex, and the drug, and the fully adjusted model included additional adjustments for methotrexate, psoriatic arthritis, body weight, and hospital. *p < 0.05; **p < 0.01; ***p < 0.001.
