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. 2022 Jul 11;9:923569. doi: 10.3389/fnut.2022.923569

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Copyright © 2022 Batalha, dos Reis Costa, Ferreira, Freitas-Costa, Figueiredo, Shahab-Ferdows, Hampel, Allen, Pérez-Escamilla and Kac.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Median concentrations of serum B-12, serum homocysteine, and milk B-12 by maternal mental health status in Rio de Janeiro, Brazil. Mann–Whitney's test was performed to compare medians (IQR) of biological samples (serum vitamin B-12, serum homocysteine, and milk vitamin B-12) at the 3rd trimester of pregnancy, 2-8 d, 28-50 d, and 88-119 d postpartum between women with and without depressive or anxiety symptoms at 3rd trimester of pregnancy (baseline), p < 0.05. Depressive symptoms were assessed by the Edinburgh Postnatal Depression Scale (EPDS), yes (EPDS ≥11, n = 36) and no (EPDS <11, n = 65) (A–C). Anxiety state was assessed by the State-Trait Anxiety Inventory (STAI), yes (STAI ≥40, n = 40), and no (STAI <40, n = 61) (D–F). Hcy, homocysteine.