TABLE 2.

the structure of some NPs with anti-CRC properties from the endophytic actinobacteria and their mechanism of action and origin.

Bacteria	Origin of bacteria	Compound name	Chemical structure	Colorectal Cell line	Host plant	country of origin	References
Streptomyces sp. YIM66403	Healthy stem of the traditional Chinese medicinal plant Isodon eriocalyx	Misamycin (186)	Anthraquinone, Quinones	SW480	Root of Isodon eriocalyx	Xishuangbanna, Yunnan, China	Li et al. (2015)
Streptomyces sp. RLe8 and Streptomyces cattleya RLe 4	Brazilian Medicinal Plant Lychnophora ericoides Mart	2,3-dihydro-2,2-dimethyl-4 (1H) –quinazolinone and Nocardamine also called deferrioxamine (187–188)	Peptides and Quinazolines	HCT-8	Lychnophora ericoides	Brazilian bioma Cerrado, brazil	Conti et al. (2016)
Streptomyces sp KIB-H1083	Traditional Chinese medicinal plant Diaphasiastrum veitchii	Glucopiericidinol A (189)	Aminoglycoside, Glycosides	SW480	Diaphasiastrum veitchii	china	Shang et al. (2018)
Micromonospora lupini Lupac 08	Root nodules of Lupinus angustifolius	Lupinacidin A and B (190–191)	Anthraquinone, Quinones	Murine carcinoma colon 26-L5	Root nodules of Lupinus angustifolius	mid-west Spain	Igarashi et al. (2007)