TABLE 3.
The structure of some NPs with anti-CRC properties from other actinobacteria and their mechanism of actions and origins.
| Bacteria | Origin of Bacteria | Compound | Chemical structure | Colorectal Cell line | Country of Origin | Special property | references |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. 1h-gs5 | Head of ant (Camponotus japonicas Mayr) | A new derivative of the spectinabilin (192) | Pyrone, Pyranes | HCT-116 | Northeast Agricultural University, Harbin of Heilongjiang province, China | — | Liu et al. (2017) |
| Streptomyces albolongus | Fresh fecal samples excreted by healthy adult Elephas maximus | 19-methoxybafilomycin C1 amide, bafilomycin C1 and bafilomycin C1 amide (193–195) | Macrolide, Lactones | Caco-2 | Xishuangbanna National Nature Reserve, Xishuangbanna, Yunnan Province, P. R. China | — | Ding et al. (2016) |
| Salinispora sp. | — | Retimycin A (196) | Quinomycin-type depsipeptide, Peptides | HCT-116 | — | — | Duncan et al. (2015) |
| Streptomyces curacoi mutant strain r25 | — | Curacozole (197) | Oxazole thiazole, Azoles | HCT-116 | — | — | Kaweewan et al. (2019) |
| Halophilic streptomyces strain (no. Hk10) | Saltern | Salternamide A (198) | Polyene, Amides | HCT-116 | Shinui Island in the Republic of Korea | Inhibition of HIF-1α accumulation, suppression of upstream signaling, Stopping the cell cycle at G2/M and induction of apoptosis | Bach et al. (2015) |
| Streptomyces sp. Scsio 1666/17c4 | Recombinant | Number 4 of ε-rhodomycinone derivatives and -rhodinose-l-rhodinose-l-rhodinoserhodomycinone (199–200) | Anthraquinone, Quinones | HCT-116 | - | - | Gui et al. (2018) |
| Streptomyces violascens | Fresh fecal samples excreted by healthy adult Ailuropoda melanoleuca (giant panda) | Fusicomycin A, fusicomycin B and isofusicomycin A (203–205) | Fusicoccane diterpene, Terpenes | HCT-116 | Yunnan Wild Animal Park, Kunming, Yunnan Province, People’s Republic of China | Anti-adhesion, anti-invasion and migration effects | Zheng et al. (2017) |
| Streptomyces sp. Gku 220 | Marine sponge sample | Rakicidin F and C (206–207) | Cyclic depsipeptide, Peptides | murine carcinoma colon 26-L5 | Andaman sea, Ranong, Thailand | Anti-invasion | Kitani et al. (2017) |
| Nanoparticle conjugated -Streptomyces sp. Js520 | Pristine sediment from the cave | Undecylprodigiosin (211) | Pyrrole, Azoles | HCT-116 | mountain Miroc in Serbia | Apoptosis | Nikodinovic-Runic et al. (2014) |
| Synthesized –Actinomycete z2039-2 | Sea Earth | K252c derivative (212) | Indolopyrazolocarbazole, Indoles | HCT-116 | coast of Qingdao, China | Apoptosis | Liu et al. (2007), Esvan et al. (2016) |