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. 2022 Jul 11;9:945632. doi: 10.3389/fvets.2022.945632

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Copyright © 2022 Wang, Liu, Chen, Yao, Liao, Liu, Sun and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gamithromycin activity against S. suis. (A,B) In vitro time-kill curves of gamithromycin against S. suis 05ZYH33 and ATCC 43765 in MH broth (MIC_MHB = 0.125 and 0.063 mg/L, respectively). (C,D) Ex vivo activity for S. suis 05ZYH33 and ATCC 43,765 in serum samples of piglets receiving intramuscular administration of gamithromycin at 6.0 mg/kg (MIC_serum = 0.016 and 0.004 mg/L, respectively). Numerical values on the right brackets represent the mean concentrations of gamithromycin in porcine serums collected at different time points.