Table 2.
Pharmacokinetic/pharmacodynamic (PK/PD) target values of gamithromycin in serum (AUC24h/MIC) needed to achieve the net stasis, 1-log10, and 2-log10 kill endpoints for each S. suis strain testeda.
| S. suis strains | MIC (mg/L) | E0 | Emax | EC50 | N | Target values of gamithromycin AUC24h/MIC ratio in serum (h)a | |||
|---|---|---|---|---|---|---|---|---|---|
| in MHB | in serum | Stasis | 1-log10 kill | 2-log10 kill | |||||
| 05ZYH33 | 0.125 | 0.016 | 2.70 | −3.41 | 26.1 | 0.67 | 20.0 | 50.1 | 158 |
| ATCC 43765 | 0.063 | 0.004 | 3.39 | −3.71 | 19.2 | 0.51 | 15.8 | 48.0 | 174 |
| Mean | NA | NA | 3.05 | −3.56 | 22.7 | 0.59 | 17.9 | 49.1 | 166 |
| SD | NA | NA | 0.35 | 0.15 | 3.45 | 0.08 | 2.10 | 1.05 | 7.85 |
a
E0, the change in bacterial density after 24 h of incubation in no drug control serum; EC50, the AUC24h/MIC ratio associated with 50% of the maximal bacterial reduction (Emax); N, the slope of the dose-response relationship; means and standard deviations (SDs) are shown in boldface; NA, not applicable.