Table 3.
Probability of attaining the typical area under the concentration (AUC24h)/MIC targets at each possible MIC value when treated with gamithromycin at the current dose of 6.0 mg/kg against S. suis infections.
| Typical AUC24h/MIC targets (h)a | PTA (%) at each possible MIC (mg/L) in MH brotha | ||||||
|---|---|---|---|---|---|---|---|
| 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | |
| 17.9 | 100 | 100 | 100 | 99.7 | 86.2 | 12.3 | 1.03 |
| 49.1 | 100 | 100 | 99.9 | 45.7 | 3.53 | 0.42 | 0.06 |
| 166 | 100 | 69.4 | 6.41 | 0.51 | 0.12 | 0.02 | 0.01 |
a
A scaling factor of 28.86 was used to bridge the MIC differences between MH broth and serum when calculating the probabilities of target attainment (PTA); the mean AUC24h/MIC ratio in serum associated with a static endpoint (i.e., 17.9 h) was used for the PK/PD cutoff determination.