TABLE 3.
An overview of clinical studies reporting on the antidiabetic properties of Moringa oleifera.
| Author, year | Country | Study population | Dose and intervention period | Clinical outcome |
|---|---|---|---|---|
| Anthanont et al. (2016) | Thailand | Healthy subjects (n = 10) | Received an oral dose of Moringa oleifera at increasing dosages of 0, 1, 2, and 4 g, and monitored for 0.5, 1, 1.5, 2, 4, and 6 h | Improved baseline insulin levels, but did not affect blood glucose concentrations |
| Taweerutchana et al. (2017) | Thailand | Therapy-naïve type 2 diabetes patients (n = 32) | Received receive either 8 g per day of Moringa oleifera leaf capsules for 4 weeks | No effect on blood glucose levels, although non-significantly improved blood pressure |
| Dixit et al. (2018) | India | Overweight participants (n = 70) | Received combined extracts of Moringa oleifera (LI85008F) at 900 mg/day (combined with modest calorie restriction and physical activity) for 16 weeks | Reduced waist and hip circumferences, and improved lipid profiles. Also, reduced low-density lipoprotein (LDL) cholesterol decreased, while high-density lipoprotein (HDL) cholesterol increased, resulting in a significantly improved LDL/HDL ratio |
| Leone et al. (2018) | Italy | Subjects with type 2 diabetes (n = 17) | Received, on 2 different days, a traditional meal supplemented with 20 g of Moringa oleifera leaf powder | Improved blood glucose control |
| Sissoko et al. (2020) | Mali | Subjects with type 2 diabetes (n = 35) | Received n 1 and 2 g respectively, of Moringa oleifera leaf powder, 30 min after eating the white bread and were monitored for up to 180 min | Reduced post-prandial glycaemia in diabetic patients |
| Gómez-Martínez et al. (2021) | Spain | Subjects with prediabetes (n = 34) | Received six daily capsules of Moringa oleifera dry leaf powder (2,400 mg/day) for 12 weeks | Improved fasting blood glucose (FBG) and glycated hemoglobin (HbA1c). However, did not affect microbiota, hepatic and renal function markers or the appetite-controlling hormones measured |
| Díaz-Prieto et al. (2022) | Spain | Subjects with prediabetes (n = 31) | Received consumed 6 × 400 mg capsule/day of Moringa oleifera dry leaf powder for 12 weeks | Plasma tumor necrosis factor alpha (TNF-α) was a significant predictor of the subject’s HbA1c response (improvement YES/NO; 77% correct classification) in the Moringa oleifera group |