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. 2022 Jul 11;13:942955. doi: 10.3389/fphar.2022.942955

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Copyright © 2022 Xiong, Li, Zhao, Li, Yu, Cui, Liu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of DSS intervention on PD based on general characteristics, behavioral manifestations, biochemical levels, and pathological changes. (A) Body weight, (B) writhing times, (C) latent period of writhing response, (D) uterine index, (E) biochemical parameters in serum (E₂, ET, and Prog), and uterine (PGE₂, PGF_2α, and β-EP), (F) representative micrographs of uterine histopathology at magnification ×100. Data are presented as the mean ± SD; *p < 0.05, **p < 0.01 vs. CON group, ^# p < 0.05, and ^## p < 0.01 vs. MOD group.