TABLE 1.
Clinical characteristics of all NCKD and CKD subjects and matched case–control study
| All subjects | Matched case–control study | |||||
|---|---|---|---|---|---|---|
| NCKD | CKD | p | NCKD | CKD | p | |
| n | 901 | 291 | ‐ | 125 | 125 | ‐ |
| Sex (male) (n/%) | 522 (57.9%) | 136 (46.9%) | 0.001 | 68 (48.6%) | 68 (48.6%) | 1.000 |
| Age (years) | 58.54 ± 0.44 | 70.55 ± 0.64 | <0.001 | 67.87 ± 0.84 | 68.01 ± 0.86 | 0.289 |
| Duration of diabetes (>10 years/%) | 207 (48.5%) | 128 (78.5%) | <0.001 | 79 (63.2%) | 79 (63.2%) | 1.000 |
| BMI (kg/m2) | 25.09 ± 0.10 | 25.29 ± 0.20 | 0.385 | 24.43 ± 0.32 | 25.07 ± 0.31 | 0.152 |
| SBP (mmHg) | 130 (120–140) | 136 (124–150) | <0.001 | 133 (120–140) | 135 (120–143.5) | 0.289 |
| DBP (mmHg) | 80 (72–86) | 78 (70–83) | 0.008 | 78 (70–83) | 79 (70–82) | 0.999 |
| HBP (%) | 299 (33.2%) | 151 (51.9%) | <0.001 | 79 (63.2%) | 79 (63.2%) | 1.000 |
| TC (mmol/L) | 4.38 ± 0.04 | 4.39 ± 0.08 | 0.893 | 4.12 ± 0.11 | 4.38 ± 0.13 | 0.089 |
| TG (mmol/L) | 1.5 (1.05–2.28) | 1.66 (1.19–2.47) | 0.025 | 1.36 (0.95–2.10) | 1.60 (1.19–2.39) | 0.016 |
| HDL (mmol/L) | 1.01 (0.84–1.22) | 0.98 (0.82–1.24) | 0.321 | 1.04 (0.83–1.27) | 0.97 (0.80–1.20) | 0.203 |
| LDL (mmol/L) | 2.79 ± 0.03 | 2.77 ± 0.07 | 0.715 | 2.62 ± 0.10 | 2.69 ± 0.11 | 0.616 |
| Cr (mmol/L) | 62 (52–74) | 103 (81–130) | <0.001 | 62 (52–75) | 102 (82–133) | <0.001 |
| UA (mmol/L) | 305.83 ± 3.14 | 375.62 ± 6.58 | <0.001 | 291.03 ± 8.42 | 368.04 ± 10.14 | <0.001 |
| eGFR (%) | 106.70 ± 0.96 | 44.31 ± 0.78 | <0.001 | 89.56 (76.7–111.91) | 51.4 (39.49–58.82) | <0.001 |
| UACR (mg/g) | 9 (5–26) | 111 (27–711) | <0.001 | 19 (5–54) | 96 (25–739) | <0.001 |
| HbA1C (%) | 8.93 ± 0.07 | 9.06 ± 0.14 | 0.377 | 8.67 ± 0.18 | 8.70 ± 0.20 | 0.911 |
| FBG (mmol/L) | 7.88 ± 0.10 | 7.45 ± 0.19 | 0.029 | 7.52 ± 0.35 | 7.80 ± 0.34 | 0.553 |
| 2hBG (mmol/L) | 12.80 ± 0.17 | 12.50 ± 0.31 | 0.401 | 13.79 ± 0.57 | 13.12 ± 0.59 | 0.375 |
| WBC (×109/L) | 6.41 ± 0.06 | 6.74 ± 0.13 | 0.018 | 6.20 ± 0.16 | 6.59 ± 0.20 | 0.139 |
| Neutrophils (×109/L) | 3.68 ± 0.05 | 4.36 ± 0.11 | <0.001 | 3.71 ± 0.13 | 4.27 ± 0.17 | 0.011 |
| Lymphocytes (×109/L) | 1.94 ± 0.02 | 1.76 ± 0.04 | <0.001 | 1.78 ± 0.06 | 1.73 ± 0.05 | 0.481 |
| NLR | 2.08 ± 0.04 | 2.86 ± 0.11 | <0.001 | 2.36 ± 0.12 | 2.79 ± 0.15 | 0.035 |
Note: Data are mean ± SE, median (interquartile range) or n (%).
Abbreviations: BMI, body mass index; CKD, chronic kidney disease; Cr, creatinine; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FBG, fasting blood glucose; HbA1C, glycosylated hemoglobin; HBP, high blood pressure; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; NCKD, without chronic kidney disease; NLR, neutrophil‐to‐lymphocyte ratio; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; UA, uric acid; UACR, urinary albumin‐to‐creatinine ratio; WBC, white blood cell; 2hBG, blood glucose 2 h after oral glucose load.