Table 1.
5-year radiographic progression-free survival, time to castration resistance, and overall survival and cox regression comparing high vs low volume disease across all four definitions.
| BCR | Low volume | High volume | p value | HR (95%CI) | p value | |
|---|---|---|---|---|---|---|
| 5-Year rPFS | ||||||
| CHAARTED | NA | 30% | 30% | 0.09 | 1.38 (0.96–1.98) | 0.09 |
| STAMPEDE | NA | 31% | 29% | 0.04 | 1.45 (1.01–2.07) | 0.04 |
| Numeric ≤3 | NA | 33% | 26% | <0.01 | 1.73 (1.21–2.48) | <0.01 |
| Numeric ≤5 | NA | 31% | 29% | 0.03 | 1.49 (1.04–2.14) | 0.04 |
| 5-year tdCRPC | ||||||
| CHAARTED | 100% | 57% | 28% | <0.01 | 2.44 (1.74–3.43) | <0.01 |
| STAMPEDE | 100% | 61% | 25% | <0.01 | 3.03 (2.16–4.27) | <0.01 |
| Numeric ≤3 | 100% | 63% | 25% | <0.01 | 3.35 (2.38–4.73) | <0.01 |
| Numeric ≤5 | 100% | 60% | 22% | <0.01 | 3.51 (2.49–4.95) | <0.01 |
| 5-Year OS | ||||||
| CHAARTED | 97% | 92% | 71% | <0.01 | 2.89 (1.60–5.24) | <0.001 |
| STAMPEDE | 97% | 95% | 68% | <0.01 | 3.82 (2.08–7.02) | <0.001 |
| Numeric ≤3 | 97% | 95% | 70% | <0.01 | 4.67 (2.50–8.74) | <0.001 |
| Numeric ≤5 | 97% | 94% | 66% | <0.01 | 3.76 (2.07–6.83) | <0.001 |
BCR biochemical recurrence, rPFS radiographic progression free survival, tdCRPC time to castration resistance, OS Overall Survival