Table 2.

Cox regression comparing between high- and low-volume disease definitions for rPFS, tdCRPC, and OS.

Definitions	HR (95%CI)	p value
High volume
rPFS (vs Numeric >3)
Numeric >5	0.95 (0.65–1.38)	0.78
CHAARTED	0.91(0.62–1.33)	0.62
STAMPEDE	0.92 (0.64–1.32)	0.64
tdCRPC (vs Numeric >3)
Numeric >5	1.11 (0.79–1.54)	0.55
CHAARTED	0.91 (0.65–1.27)	0.59
STAMPEDE	0.98 (0.71–1.35)	0.89
OS (vs Numeric >3)
Numeric >5	1.02 (0.59–1.75)	0.96
CHAARTED	0.87 (0.51–1.51)	0.63
STAMPEDE	0.95 (0.56–1.60)	0.84
Low Volume
rPFS (vs Numeric ≤3)
Numeric ≤5	1.10 (0.78–1.54)	0.59
CHAARTED	1.09 (0.77–1.53)	0.63
STAMPEDE	1.13 (0.81–1.58)	0.48
tdCRPC (vs Numeric ≤3)
Numeric ≤5	1.09 (0.77–1.53)	0.64
CHAARTED	1.07 (0.75–1.51)	0.72
STAMPEDE	1.21 (0.87–1.70)	0.26
OS (vs Numeric ≤3)
Numeric ≤5	1.28 (0.66–2.48)	0.47
CHAARTED	1.14 (0.57–2.29)	0.71
STAMPEDE	1.38 (0.71–2.68)	0.34

rPFS radiographic progression free survival, tdCRPC time to castration resistance, OS Overall Survival