TABLE 2.

Examples of clusters which both reflect (67, 14, 341, 213) and do not reflect (70, 49, 403) their programmatically generated scores. The table includes a cluster identifier (Cluster Number), calculated relatedness score from the NLP analysis (Score), relatedness category from manual review (Category), description of the overarching theme of the cluster (Description), and the ARIC variables in the cluster (Variables). Clusters were selected to highlight cases of agreement and disagreement between programmatic scoring and reviewer category assignment. See Supplemental Table S1 for all clusters.

Cluster Number	Score	Category	Description	Variables
67	42.0	Exact	lung health history (lung disease)	Has a doctor ever said that you had any of the following: chronic lung disease, such as chronic bronchitis, or emphysema? Q10g [Home Interview, exam 1]
				[Medical care]. Has a doctor ever said you had any of the following: (read each disease name and code N if No or Never Tested). Q5. Chronic lung disease, such as chronic bronchitis, or emphysema. Q5E [Health/Medical History, exam 2]
14	24.7	Highly Related	lung health history (asthma)	[Asthma]. Ever had asthma? Q35 [Respiratory Symptoms and Physical Activity Form, exam 1]
				[Asthma]. Age asthma started Q37 [Respiratory Symptoms and Physical Activity Form, exam 1]
				[Asthma]. Age asthma stopped. Q39 [Respiratory Symptoms and Physical Activity Form, exam 1]
				[Wheezing]. Age at first attack. Q18 [Respiratory Symptoms and Physical Activity Form, exam 1]
				Has a doctor ever said that you had any of the following: asthma? Q10h [Home Interview, exam 1]
				[Medical care]. Has a doctor ever said you had any of the following: (read each disease name and code N if No or Never Tested). Q5. Asthma. Q5F [Health/Medical History, exam 2]
				[Medical care]. Has a doctor ever said you had any of the following? Asthma. Q6e [Personal History form, exam 4]
				[Asthma]. Still have asthma? Q38 [Respiratory Symptoms and Physical Activity Form, exam 1]
				[Wheezing]. Short Of Breath Wheezing Attack? Q17 [Respiratory Symptoms and Physical Activity Form, exam 1]
341	16.4	Related	lung health history (cough/wheezing)	[Wheezing]. Number years this wheezy or whistling sound been present. Q16 [Respiratory Symptoms and Physical Activity Form, exam 1]
				[Cough]. Number years had trouble with phlegm. Q12 [Respiratory Symptoms and Physical Activity Form, exam 1]
213	7.8	Unrelated	diet	[Other dietary items]. Enter code and specify brand and form below. Q78 [Dietary Intake Form (DTIC), exam 3]
				[Other dietary items]. What kind of fat do you usually use for baking? Q77 [Dietary Intake Form (DTIC), exam 3]
70	6.0	Exact	medication (cholesterol lowering)	Cholesterol lowering medication W/in 2 weeks.: using 2004 Med. code, visit 2 [Cohort, Exam 2]
				Used statin (at visit 2) last 2 weeks (0 = no, 1 = yes) based on 2004 Med. code [Cohort, Exam 2]
49	5.7	Exact	blood pressure measurements (ankle brachial)	Ankle Brachial Index, visit 1, definition 4 [Ankle Brachial Index Data, exam 1]
				Ankle-Brachial index return [Ankle Brachial BP (Blood Pressure—ultrasound work station), exam 1]
403	50.0	Related	medication	[Medication records]. Medication code number. Q12B [Medication Survey Form, exam 2]
				[Medication records]. Medication code number. Q11B [Medication Survey Form, exam 2]