. 2022 Jul 11;13:925913. doi: 10.3389/fgene.2022.925913

TABLE 4.

HDR outcomes in embryos dependent on editor delivery as DNA, RNA or RNP.

Mutation	Editor	Delivery	Mosaic HDR	Complete HDR
PMEL: ΔCTT (p.Leu18del)	gRNA 129F/Cas9, ssODN 1288	DNA	85% (60/71) ^a	8% (6/71)
		RNA	60% (50/84) ^b	11% (9/84)
		RNP	17% (8/47) ^c	6% (3/47)
	TALEN TR17/TL217, ssODN 1288	DNA	57% (42/74) ^a	39% (29/74) ^a
	TALEN TR17/TL217, ssODN 1288	RNA	90% (63/70) ^b	3% (2/70) ^b
PRLR: ΔC (p.L462*)	gRNA 634/Cas9, ssODN 1446	DNA	18% (4/22)	5% (1/22)
		RNA	25% (6/24)	0% (0/24)
		RNP	42% (5/12)	8% (1/12)
PRLR: T > A (p.C440*)	gRNA 632/Cas9, ssODN 1403	DNA	39% (19/49) ^a	6% (3/49)
PRLR: T > A (p.C440*)	gRNA 632/Cas9, ssODN 1403	RNA	64% (48/84) ^b	7% (6/84)

^abcValues with different superscripts within a column differ p < 0.05.