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. 2022 Jul 11;10:886316. doi: 10.3389/fcell.2022.886316

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Copyright © 2022 Fallatah, Cui, Di Pietro, Carter, Pounder, Dorninger, Pifl, Moser, Berger and Braverman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pex7 genotype correlates with survival rates and weight gain. Kaplan–Meier plots showing the percentage of survival of Pex7 deficient mice (n = 41–60 per genotype). Analyzing the survival data by log rank tests showed significant differences between genotypes (p < 0.001) in accordance to the severity of Pex7 genotype (A). Graded and significant reduction in body weight according to Pex7 genotype severity is found in Pex7 mutants compared to controls at 1, 4, and 12 months (M) of age (n = 10–12 per genotype) (B). ns: nonsignificant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.